nephrogenic adenoma

neph·ro·gen·ic ad·e·no·ma

a benign tumor of the urinary bladder or urothelium, composed of glandular structures resembling renal tubules.

nephrogenic adenoma

A benign lesion which is more common in women and arises in urothelium-lined structures, especially the bladder, which often contains scant amounts of crystalloid material. It is regarded as a metaplastic response to mechanical trauma—e.g., recurrent UTIs, stones, diverticuli, urinary tract instrumentation, ulcers, infection, ureteric stents, intravesical therapy and open bladder surgery.

DiffDx
Prostate adenocarcinoma (tubular structures), clear cell (hobnailing) carcinoma, in situ adenocarcinoma. 

Presence of tubules, cords, and signet ring-like cells; prominent nucleoli; muscle involvement; blue-tinged mucinous secretions; focal prostate specific antigen and PSAP positivity; and negative staining for high molecular weight CK (34betaE12).
References in periodicals archive ?
7,9) Another papillary/ polypoid lesion that might also enter into the broad differential is the papillary variant of nephrogenic adenoma, mainly because it is frequently misdiagnosed or misinterpreted.
Nephrogenic adenoma of the urinary bladder is a rare lesion which could easily be confused with or could easily be misdiagnosed as a number of malignant lesions of the urinary bladder.
The differential diagnosis may be sometimes challenging and includes primarily the urothelial (transitional cell) carcinoma and rarely the nephrogenic adenoma, the paraganglioma and the carcinoid tumours.
The histological differential diagnosis of paraganglioma includes nested variant of TCC, inverted papilloma and nephrogenic adenoma.
Several lesions can have an exophytic papillary or polypoid cystoscopic appearance, including papillary urothelial neoplasms, polypoid cystitis, and nephrogenic adenoma.
1] Nephrogenic adenoma (also named nephrogenic metaplasia) is a benign entity and a common mimic of adenocarcinoma; this presents a diagnostic challenge in the interpretation of bladder biopsies.
The histologic differential diagnosis of miillerianosis of the urinary bladder encompasses several benign and neoplastic conditions, including cystitis glandularis, urachal remnants, nephrogenic adenoma, primary adenocarcinomas of the urinary bladder, and secondary spread from a minimal-deviation adenocarcinoma of the uterine cervix.
Vesical nephrogenic adenoma is a rare, benign entity that appears most commonly in middle-aged males.
The benign lesions include cystitis cystica, cystitis glandularis, von Brunn nests, nephrogenic adenoma, mesonephric remnant, intestinal metaplasia, and urachal remnant.
Perhaps the most controversial aspect of nephrogenic adenoma is its derivation and whether it represents a metaplasia or a benign tumor.
25,27) Nephrogenic adenoma is the most important differential diagnosis.
This case is an example of a nephrogenic adenoma with some unusual morphologic features; however, given the patient's history of previous resections, this is not an unexpected diagnosis.