nephrogenic adenoma

neph·ro·gen·ic ad·e·no·ma

a benign tumor of the urinary bladder or urothelium, composed of glandular structures resembling renal tubules.

nephrogenic adenoma

A benign lesion which is more common in women and arises in urothelium-lined structures, especially the bladder, which often contains scant amounts of crystalloid material. It is regarded as a metaplastic response to mechanical trauma—e.g., recurrent UTIs, stones, diverticuli, urinary tract instrumentation, ulcers, infection, ureteric stents, intravesical therapy and open bladder surgery.

DiffDx
Prostate adenocarcinoma (tubular structures), clear cell (hobnailing) carcinoma, in situ adenocarcinoma. 

Presence of tubules, cords, and signet ring-like cells; prominent nucleoli; muscle involvement; blue-tinged mucinous secretions; focal prostate specific antigen and PSAP positivity; and negative staining for high molecular weight CK (34betaE12).
References in periodicals archive ?
The differential diagnosis may be sometimes challenging and includes primarily the urothelial (transitional cell) carcinoma and rarely the nephrogenic adenoma, the paraganglioma and the carcinoid tumours.
The benign lesions include cystitis cystica, cystitis glandularis, von Brunn nests, nephrogenic adenoma, mesonephric remnant, intestinal metaplasia, and urachal remnant.
1] Nephrogenic adenoma (also named nephrogenic metaplasia) is a benign entity and a common mimic of adenocarcinoma; this presents a diagnostic challenge in the interpretation of bladder biopsies.
Perhaps the most controversial aspect of nephrogenic adenoma is its derivation and whether it represents a metaplasia or a benign tumor.
Vesical nephrogenic adenoma is a rare, benign entity that appears most commonly in middle-aged males.
25,27) Nephrogenic adenoma is the most important differential diagnosis.
This case is an example of a nephrogenic adenoma with some unusual morphologic features; however, given the patient's history of previous resections, this is not an unexpected diagnosis.
Although some, such as nephrogenic adenoma, can be seen in different locations, most are identified in particular organs and, as such, have unique differential diagnostic considerations specific to that organ.
The differential diagnosis of CCA includes nephrogenic adenoma and other benign reactive processes, as well as primary malignant tumors of the urinary bladder and metastases to the urinary bladder.
The differential diagnosis of micropapillary TCC includes nephrogenic adenoma and clear cell carcinoma.
Although nephrogenic adenoma has been reported to result in abnormal urine cytologic test results,[11,12] we found no reference to urine cytologic testing in patients with BPEPs.
Nephrogenic adenomas may show papillary structures, but the lining cells are usually a single layer of cuboidal, flat, or "hobnailed" cells with no conspicuous cellular atypia.