systemic fibrosis (nephrogenic
A competing theory suggests that spindle cells resemble intralobar nephrogenic
rests and that these lesions may lie within the pathologic spectrum of Wilms' tumours.
NSF is only observed in patients with severe renal dysfunction, primarily patients undergoing or approaching dialysis, hence the use of nephrogenic
in its name.
However, recent studies have discovered harmful side effects, such as nephrogenic
systemic fibrosis, stemming from the use of this contrast agent in some patients, forcing the Food and Drug Administration (FDA) to place restrictions on the clinical use of gadolinium.
In addition, there have been a few reactions to the gadolinium contrast agent and there is evidence to suggest a link to nephrogenic
Collectively, these data indicate that nephrogenic
deficits induced by BaP require integrity of AHR signaling and involve interference with coordinated renal cell differentiation programming.
Ferumoxytol may be an alternative to gadolinium-based contrast agents, which have been associated with nephrogenic
systemic fibrosis (NSF) in patients with Stage 4-5 CKD and acute kidney injury (Elmholdt et al.
Pope: Systemic sclerosis can be confused with such sclerodermalike skin disorders as eosinophilic fasciitis (EF), morphea, scleromyxedema, and nephrogenic
systemic fibrosis (NSF).
Kidney patient Margaret Roxburgh, 54, was diagnosed with nephrogenic
systemic fibrosis days after being injected with Omniscan.
The ailment, which is sometimes fatal, is called nephrogenic
fibrosing dermopathy and has been reported in patients with weakened kidney function.
Drawbacks include the high cost of MRA and the potential for nephrogenic
systemic fibrosis in patients with renal insufficiency (14).
diabetes insipidus: renal effects of amiloride.