A predisposition to FSGS may begin in utero, as impairment in the process of nephrogenesis
will result in fewer layers of nephrons within the kidney and a reduced renal mass.
10) For example, both PAX2 and PAX8 are abundantly expressed by renal blastemal cells during nephrogenesis
, then are noted in only a few renal parenchymal cells in mature kidney, but are identified again in RCC.
Uteroplacental insufficiency alters nephrogenesis
and downregulates cyclo oxygenase-2 expression in a model of IUGR with adult-onset hypertension.
Fetal exposure to a maternal low protein diet impairs nephrogenesis
and promotes hypertension in the rat.
Calcium/ NFAT signalling promotes early nephrogenesis
Pritchard-Jones K: The Wilms tumour gene, WT1, in normal and abnormal nephrogenesis
The developmental increase in glomerular filtration rate (GFR) relies on the existence of normal nephrogenesis
Glomerulogenesis and de novo nephrogenesis
in medaka fish - evolutionary approach
However, the mechanism by which aryl hydrocarbon receptor (AHR) regulates genetic elements during nephrogenesis
has not been explained.
30-32) During nephrogenesis
, PAX-2 appears very early in the renal blastema and promotes mesenchymal cell proliferation and apoptosis, and mesenchymal-epithelial transformation, with formation of immature renal tubules and glomeruli.
BACKGROUND: The use of experimental model systems has expedited the elucidation of pathogenetic mechanisms of renal developmental disease in humans and the identification of genes that orchestrate developmental programming during nephrogenesis
In the 1920s to 1930s, after the dual origin of ampullary bud and nephrogenic blastema in nephrogenesis
was more widely recognized, cyst formation, resulting from failure of the 2 tissues to unite, emerged as the most popular theory.