neostigmine


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Related to neostigmine: Pyridostigmine, Edrophonium, glycopyrrolate

neostigmine

 [ne″o-stig´mēn]
an anticholinesterase and prokinetic agent used for the symptomatic treatment of myasthenia gravis, for prevention and treatment of postoperative stasis and atony of the gastrointestinal tract or urinary bladder, and for reversal of the effects of certain neuromuscular blocking agents, such as tubocurarine, after surgery. Available as neostigmine bromide and neostigmine methylsulfate.

neostigmine

(nē′ō-stĭg′mēn, -mĭn)
n.
A cholinesterase inhibitor that is given in the form of a bromide salt, C12H19BrN2O2, or a methyl sulfate, C13H22N2O6S, used to treat myasthenia gravis and muscle atony and to reverse the effects of muscle relaxants after surgery.

neostigmine

Pharmacology An anticholinesterase used for the symptomatic therapy of myasthenia gravis and, in anesthesiology, to reverse the effects of depolarizing agents. See Myasthenia gravis, Reversal agent.

neostigmine

An ANTICHOLINESTERASE drug used in the treatment of MYASTHENIA GRAVIS. Neostigmine interferes with the enzyme that breaks down the neurotransmitter ACETYLCHOLINE and so prolongs its action. The drug is on the WHO official list. A brand name is Robinul neostigmine.

neostigmine

A reversible anticholinesterase drug, which neutralizes the effect of acetylcholinesterase and thereby allows the prolonged action of acetylcholine on the iris and ciliary muscle. Its action is similar to physostigmine but it is not so irritating a miotic. Both are occasionally used in the treatment of glaucoma. See acetylcholine; parasympathomimetic; physostigmine; miosis; miotics.
References in periodicals archive ?
Spinal neostigmine apparently activates descending pain inhibitory system that rely on a spinal cholinergic interneuron, probably exacerbating a cholinergic tonus that is already activated during the postoperative period [12] and seems to be extremely efficient for alleviating somatic pain.
The examined factors were the inflammatory state and AChE inhibitor-treatment (donepezil or neostigmine).
When TOF25 was reached, sugammadex [IV; 2 mg/kg (current body weight (CBW)] or neostigmine (IV; 0.03 mg/kg) and atropine [0.01 mg/kg; CBW) were administered.
The reversal of neuromuscular blockade was performed in 57% of patients and in all cases neostigmine was used at doses between 20 and 25mcg/kg.
Lu, "The effect of dexamethasone on postoperative pain emesis after intrathecal neostigmine," Anesthesia and Analgesia, vol.
The results of blood hormones concentration obtained only after treatment period, GnRH content in the POA, GnRHR protein expression, and all examined genes expression were analysed using a two-way ANOVA, the examined factors were inflammatory state and AChE inhibitor treatment (Donepezil or Neostigmine).
Pharmacologic therapy with cholinergic drugs: Intravenous administration of neostigmine was considered if the cecal diameter was > 10 cm after applying the treatment described above without signs of amelioration within 24 hours or cecal diameter of > 12 cm [14, 15].
In the current study, we measured the time-response curves of two clinically relevant concentrations of neostigmine to more intensively investigate the effects of sepsis on the potency of anticholinesterase drugs.
There are other inhibitors which bind at both esteric as well anionic site of the enzyme like neostigmine. Such enzyme-inhibtor complexes are more stable and not easily hydrolysable and need reactivators to hyrolyse such complexes.
At the end of the surgery, the patient was administered Ondansetron 4mg and Pethidine 50mg (in 2mL), and reversed with Neostigmine 2.5mg and Glycopyrrolate 0.4mg.
Flamel currently has approvals for and markets two previously Unapproved Marketed Drugs in the USA, Bloxiverz (neostigmine methylsulfate injection) and Vazculep (phenylephrine hydrochloride injection).