Although HTLV-1 infection alone is not sufficient in and of itself to result in neoplastic transformation
, the virus does express a few genes demonstrated to aid in oncogenesis (1).
One of the two non-resistant lines and its resistant clone were deficient in their DNA mismatch repair systems, which results in genetic instability, increased susceptibility to neoplastic transformation
, and greater development of chemoresistant cells.
9,11-13) We hope that along with elucidation of the molecular mechanism for lineage conversion of B-cell neoplasms, the dynamic process of this unconventional neoplastic transformation
will be better understood and therapeutic interventions will be better targeted.
4) In these cases, persistence of infection, viral integration and activation of inflammatory pathways have been linked to neoplastic transformation
and malignant progression.
The dome and posterior bladder wall was thinned out in areas of about 5 cm with suspicion of a neoplastic transformation
, and a 3 mm perforation was identified from which there was leaking bloodstained urine (Fig.
A causal role for ERG in neoplastic transformation
of prostate epithelium.
Duodenal carcinoma with neoplastic transformation
of the underlying Brunner's glands.
936) investigated the effects of arsenite on the inactivation of p53--a step implicated in the initiation of cancer--and neoplastic transformation
of human embryo lung fibroblast (HELF) cells.
Changes in nuclear size and morphology associated with neoplastic transformation
are observable using confocal imaging.
Therefore, loss of normal function of any of these oncogenes could be the first step leading to neoplastic transformation
and proved to be involved in paediatric HL.
The tumor suppressor gene p53 regulates the cell cycle and prevents neoplastic transformation
Beyond prognosis and prediction, miRNAs associated with neoplastic transformation
maymediate pathophysiological mechanisms underlying tumorigenesis.