neoplastic meningitis


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ne·o·plas·tic men·in·gi·tis

infiltration of subarachnoid space by neoplastic cells, typically medulloblastoma or metastatic carcinoma.
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Diagnostic tools for neoplastic meningitis: detecting disease, identifying patient risk, and determining benefit of treatment.
Neoplastic meningitis, a particular manifestation of CNS recurrence, results from the infiltration of metastatic cells into the cerebrospinal fluid and meninges.
Patients with neoplastic meningitis usually have accompanying headache, meningeal signs, and evidence of increased ICP.
(14.) Grossman SA, moynihan TJ (1991) Neoplastic meningitis. NeurClin 9:842-56.
A retrospective study from 1944 to 2002 revealed 21 patients with gastrointestinal primary tumors and neoplastic meningitis. The frequency of leptomeningeal involvement in gastric adenocarcinoma was 8 out of 5618 patients (0.14%) and 7 out of 4361 (0.16%) in esophageal adenocarcinoma [1].
Neoplastic meningitis is due to dissemination of malignant cells to the leptomeninges and the subarachnoid space.
Neoplastic meningitis is more likely to occur in patients with disseminated cancer, but in, respectively, 20% and 10% of cases it may manifest after a disease-free period or as a first manifestation of systemic tumors [2].
Their topics include the pathology and molecular genetics of common brain tumors, malignant gliomas in adults, low grade astrocytomas, pediatric neuro-oncology, the managing intramedullary spinal cord tumors, medical complications in the management of brain tumor, brain metastases, neoplastic meningitis, the neurotoxicity of chemotherapy, paraneoplastic disorders, and neurological complications of bone marrow and organ transplantation.
Its two marketable products are DepoCyt for treating cancer-related neoplastic meningitis and DepoDur for the treatment of post-operative pain.