Maternal and fetal factors associated with mortality and morbidity in a multi-racial/ethnic registry of anti-SSA/Ro-associated cardiac neonatal lupus
Beta2-glycoprotein-I and Protection from Anti-SSA/Ro60 Associated Cardiac Manifestations of Neonatal Lupus
J Immunol 2011; 187: 520-6.
One to 2 percent of babies born to mothers with certain autoantibodies (SSA-Ro and/or SSB-La) are born with neonatal lupus
, a condition that often resolves itself within three to six months.
The cutaneous manifestations of neonatal lupus
erythematosus can tip you off to this condition, she said.
erythematosus: A clinical, serological and immunogenetic study with review of the literature.
comprises several fetal and neonatal manifestations that share in common the in utero exposure to maternal anti-SSA/Ro antibodies (with or without anti-SSB/ La antibodies).
can affect babies of mothers with SSA/Ro and SSB/La autoantibodies, and can appear as a transient rash that disappears by the time the baby is about 6 months old, or, in rare cases, as a transient abnormal blood or liver condition.
Diagnosis: Neonatal lupus
This infant has neonatal lupus
erythematosus, a rare syndrome in which maternal autoantibodies are passively transferred to the baby and cause cutaneous lesions or isolated congenital heart block.
Curiously, there is no evidence to date that SLE patients' offspring suffer an increased incidence of autoimmune SLE or that infants with neonatal lupus
are at an increased risk.
13) These antibodies are also associated with neonatal lupus
syndrome and congenital heart block.
can affect some newborn babies of women with SLE or certain other immune system disorders.
Currently, the chip identifies antibodies associated with approximately 10 different collagenosis and vasculitis-related autoimmune diseases, including systemic and neonatal lupus
and systemic sclerosis.