neonatal lupus


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ne·o·na·tal lu·pus

lupus erythematosus occurring in newborn children of mothers who had lupus during pregnancy; screens to measure anti-SSA antibodies usually should be undertaken; 50% have antinuclear antibodies. Various skin lesions are seen, which can resolve or leave scars; the syndrome usually resolves; however, cardiac manifestations can be fatal. Some children develop lupus erythematosus later in life.

neonatal lupus

Rash, abnormally low platelet counts, liver and brain disease, and congenital heart block occurring in an infant whose mother has systemic lupus erythematosus. The disease results from the passage of maternal autoantibodies to the developing fetus. Although most of the findings resolve spontaneously, congenital heart block does not, and it may require the insertion of a pacemaker.
See also: lupus
References in periodicals archive ?
Pregnancy in systemic lupus erythematosus and neonatal lupus. In: Hochberg MC, Silman AJ, Smolen JS editors.
Cardiac manifestations of neonatal lupus a review of autoantibody-associated congenital heart block and its impact in an adult population.
Both twins were investigated for neonatal lupus and workup turned out to be positive for Anti-SSA/Ro antibodies with titers 5-6 folds higher than normal and a positive 1+ speckled ANA in both twins.
Adelowo, "Neonatal lupus syndrome in a Nigerian child," Case Reports, 2012.
Anti-Ro pozitif olan hastalardan dogan bebeklerde konjenital kalp blogu, idiyopatik kardiyomiyopati ve neonatal lupus da gelisebilir (29).
Epidemiology, etiology, detection and treatment of autoantibody-associated congenital heart block in neonatal lupus. Curr Rheumatol Rep.
One to 2 percent of babies born to mothers with certain autoantibodies (SSA-Ro and/or SSB-La) are born with neonatal lupus, a condition that often resolves itself within three to six months.
Madison was diagnosed with cutaneous neonatal lupus. Her ECG was normal.
The cutaneous manifestations of neonatal lupus erythematosus can tip you off to this condition, she said.
Annular erythemas may be associated with a several immunologic abnormalities including subacute cutaneous lupus erythematosus (1), autoimmune annular erythema (2), and neonatal lupus erythematosus (3).
Neonatal lupus comprises several fetal and neonatal manifestations that share in common the in utero exposure to maternal anti-SSA/Ro antibodies (with or without anti-SSB/ La antibodies).
Neonatal lupus, a very rare condition in newborns, results from the passage of autoantibodies from the mother to her baby, specifically anti-Ro/SSA or anti-La/SSB, which can affect the skin, heart and blood of the fetus and newborn.

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