neonatal hyperbilirubinemia

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ne·o·na·tal hy·per·bil·i·ru·bi·ne·mi·a

serum bilirubin exceeding 12.9 mg/dL (220 μol/L) or rising at a rate greater than 5 mg/dL per day; also applied to a nonphysiologic pattern of hyperbilirubinemia, that is, jaundice in the first 24 hours of life or extending beyond the first week of life in term infants.

neonatal hyperbilirubinemia

ne·o·na·tal hy·per·bi·li·ru·bi·ne·mi·a

(nē'ō-nā'tăl hī'pĕr-bil'i-rū-bi-nē'mē-ă)
Serum bilirubin greater than 12.9 mg/dL (220 mcmol/L) or rising at a rate greater than 5 mg/dL per day; also applied to a nonphysiologic pattern of hyperbilirubinemia, i.e., jaundice in the first 24 hours of life or extending beyond the first week of life in term infants.


pertaining to the period immediately after birth; the duration varies between species; in humans refers to the first four weeks of life; in animals the first week seems appropriate. Some neonatal disorders are listed in entries below. Others are listed elsewhere under titles specific to their anatomic location, including hyaline membrane disease, respiratory distress syndrome.

neonatal cardiac murmur
is observed in foals and most disappear before the fifth day. Persistence after that time may suggest valvular dysfunction. Many congenital murmurs are functional and cause no signs of disease.
neonatal diarrhea
see undifferentiated diarrhea of the newborn.
neonatal distress
see neonatal maladjustment syndrome (below).
neonatal edema
usually caused by obstruction to lymphatic flow by defective development of lymph drainage system.
neonatal hyaline membrane disease
see hyaline membrane disease.
neonatal hyperbilirubinemia
see neonatal jaundice (below).
neonatal hypoglycemia
a metabolic disease of newborn piglets caused by restriction of food intake. Clinical signs include weakness, shivering, hypothermia and terminal convulsions.
neonatal isoerythrolysis
see alloimmune hemolytic anemia of the newborn.
neonatal isoimmune purpura
see neonatal thrombocytopenic purpura (below).
neonatal jaundice
is an important clinical sign in foals because of the possibility of alloimmune hemolytic anemia. Some cases of benign, physiological jaundice also occur in foals. There is jaundice but no other clinical or pathological abnormality. Called also neonatal hyperbilirubinemia.
neonatal maladjustment syndrome
a disease of newborn thoroughbred foals caused by premature severance of the umbilical cord in assisted foalings and by hypoxia due to other causes. The foals may be normal for some hours after birth. Clinical signs include aimless wandering, apparent blindness, and convulsions including a sound like a dog barking. Called also barkers and wanderers.
neonatal mortality
death in the neonatal group.
neonatal neoplasm
occurs rarely. Lymphosarcoma, benign and malignant melanoma and myeloid leukosis are recorded. Sporadic bovine leukosis, manifested by many subcutaneous tumors, is the most common form of the disease.
neonatal ophthalmia
see ophthalmia neonatorum.
neonatal septicemia
many bacteria, which are not widely invasive in older animals, can cause septicemia in neonates because of their immunological immaturity; common examples are Escherichia coli, Listeria monocytogenes, Salmonella spp., streptococci, e.g. S. suis.
neonatal spasticity
an inherited disease of calves which are normal at birth but soon develop a susceptibility to tetanic convulsions when stimulated. See also neuraxial edema.
neonatal streptococcal infection
occurs in all species, but is especially important in piglets and foals. Bacteremia and septicemia may result in the animal's death or the development of arthritis, endocarditis, meningitis or ophthalmitis. Causative bacteria are: foals—Streptococcus zooepidemicus (S. pyogenes equi); piglets—S. suis types 1 and 2, S. equisimilis; calves—S. pyogenes; lambs—S. faecalis and group C streptococci.
neonatal thrombocytopenic purpura
a severe bleeding disease in piglets a few days old which have drunk colostrum containing antiplatelet antibody from their alloimmune dam.
neonatal vigor
amount of physical activity displayed by the newborn animal; an indication of the potential viability of the patient.
References in periodicals archive ?
Risk factors for neurotoxicity in newborns with severe neonatal hyperbilirubinemia.
Stanate(R) (stannsoporfin) is an investigational drug in late stage development for the treatment of severe neonatal hyperbilirubinemia and possible prevention of kernicterus, a neurological condition attributed to high levels of bilirubin in the brain that some believe is on the rise in the United States.
They specifically emphasize the principles of patient safety and the key role of timeliness of interventions to prevent adverse outcomes resulting from neonatal hyperbilirubinemia.
Neonatal hyperbilirubinemia is usually a benign condition, peaking 2-4 days after birth, that requires no intervention.
Neonatal hyperbilirubinemia and longterm outcome: another look at the collaborative perinatal project.
If this trial is successful and becomes routine, the ability to grade proficiency testing participants for accuracy, using target values determined by the reference method, could become a valuable contribution toward improving the quality of bilirubin assays, which is essential for the management of neonatal hyperbilirubinemia.
Prevention of neonatal hyperbilirubinemia in non-human primates by Zn-protoporphyrin.

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