neomycin


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neomycin

 [ne″o-mi´sin]
a broad-spectrum aminoglycosideantibiotic produced by Streptomyces fradiae, effective against a wide range of gram-negative bacilli and some gram-positive bacteria. It is used, as the sulfate salt, for urinary tract irrigation, administered orally to prepare the bowel for surgery, and applied to the skin, eyes, and ears to treat infections due to susceptible organisms. In topical preparations it is often combined with other antibiotics or antiinflammatory steroids.

neomycin

/neo·my·cin/ (-mi´sin) a broad-spectrum aminoglycoside antibiotic produced by Streptomyces fradiae, effective against a wide range of gram-negative bacilli and some gram-positive bacteria; used as the sulfate salt.

neomycin

(nē′ə-mī′sĭn)
n.
A broad-spectrum antibiotic produced from strains of the actinomycete Streptomyces fradiae and used especially in the form of its sulfate as an intestinal antiseptic in surgery.

neomycin

Infectious disease A broad-spectrum aminoglycoside antibiotic obtained from Streptomyces fradiae, which is generally effective against gram-negative rods and some gram-positive cocci

neomycin

An aminoglycoside antibiotic drug derived from a strain of Streptomyces fradiae . Neomycin can be given by mouth to destroy organisms in the bowel or can be used in solution to irrigate the bladder. It is poorly absorbed into the bloodstream. It is much too toxic to be given by injection and can have seriously damaging effects on hearing and on the kidneys. The drug is widely used as a surface application in ointments with other ingredients such as steroids. A brand name is Nivemycin. Preparations of neomycin with a corticosteroid, for external use, include Audicort, Betnovate-N, Dermovate-NN, Maxitrol, Neo-Cortef, Synalar-N, Tri-Adcortyl and Vistamethasone N. The drug is also formulated with the antibiotics polymyxin and gramicidin and with the antifungal drug nystatin.

neomycin (nē´ōmī´sin),

n an antibiotic secured from cultures of
S. fradiae, used for preoperative sterilization. It is a constituent of topically applied ointments, solutions, and troches because of its antibacterial action against gram-negative organisms.

neomycin

an aminoglycoside antibiotic produced by Streptomyces fradiae; the sulfate is used as an intestinal antiseptic and in treatment of systemic infections due to gram-negative bacteria. High doses and prolonged treatment can be nephrotoxic and ototoxic.

neomycin B
References in periodicals archive ?
Keywords: Chronic Suppurative Otitis Media (CSOM), Topical Ciprofloxacin, Topical Neomycin.
Overall, increasing the neomycin concentration in treatment conditions correlated with decreasing percentages of intact hair cells, increasing percentages of damaged hair cells, and increasing percentages of missing hair cells in the region of interest (Fig.
In these structures, the neomycin constitution was kept intact as a recognition element to rRNA, while the extended sugar ring of each structure was designed to enhance the binding affinity.
The patient who is prescribed neomycin should be assessed for concurrent renal impairment along with liver dysfunction as use of this medication may increase the risk for ototoxicity and nephrotoxicity.
The USA300 isolate detected at Nagoya Medical Center in 2004 was bacitracin resistant and neomycin susceptible.
Can cause anaphylactic reaction to previous rubella vaccine, eggs, or neomycin.
Even if bacterial contamination were to occur before generation, the presence of neomycin would serve only to prevent additional bacterial growth; it would not address the strong degradation activity that we monitored with the degradation calibrator.
coli 27 EC 27 MIC MIC combined Antibiotics EEHM (32 [micro]g/ml) Amikacin 64 [greater than or equal to] 1 Gentamicin 8 [greater than or equal to] 1 Kanamycin 256 2 Neomycin 16 3 Tobramycin 32 [greater than or equal to] 1 Chlorpromazine 64 -- Antibiotics CPZ (16 [micro]g/ml) Amikacin 16 Gentamicin 8 Kanamycin 8 Neomycin 16 Tobramycin [greater than or equal to] 1 Chlorpromazine -- EEHM, Ethanolic extract of H.
over 3700 allergens have been implicated (3); the most common allergens being nickel sulphate, bacitracin, neomycin sulphate, fragrance mix, and quaternium-15 (4).
But, was compared, cream and neomycin were found significantly potent than placebo.
Directed at new researchers without the benefit of a couple of decades of work in the field, this explains the initial work of Selman Waksman to produce streptomycin, then proceeds to such topics as the biochemistry and genetics of aminoglycoside producers, mechanics of aminoglycoside antibiotic resistance, the development and action of kanamycin and neomycin class antibiotics, NMR structural studies and RNA interaction, structural comparisons between prokaryotic and eukaryotic ribosomal decoding, binding of antibiotics to the aminoacyl-tRNA site of bacterial ribosome, the chemistry and biological relevance of metalloaminoglycosides, adverse effects of aminoglycoside therapy, new efforts at targeting HIV-1 RNA, and novel targets for aminoglycosides.