neointimal hyperplasia


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neointimal hyperplasia

An increase in the thickness of the lining of a blood vessel in response to injury or vascular reconstruction. It is an important cause of vein graft obstruction after coronary artery bypass surgery and in the premature closure of other vascular conduits, e.g., in dialysis access devices. It is characterized by the migration of smooth muscle cells into the graft, followed by the release of cytokines that damage the vessel wall and contribute to its degradation by inflammation.
See also: hyperplasia
References in periodicals archive ?
The aim of this study was to investigate the possible inhibitory effects of zoledronic acid (ZA) as an MMP inhibitor on neointimal hyperplasia in a rabbit-model of carotid anastomosis.
During surgical or interventional vascular procedures, the vulnerable lining of the vessel is injured, which leads to a local cascade of unwanted events, from initial inflammation to delayed neointimal hyperplasia (vessel scarring).
Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis.
Metallic Surface Treatment Using Electrochemical Polishing Decreases Thrombogenicity and Neointimal Hyperplasia of Coronary Stents.
Dosimetric considerations for catheter-based [beta] and [gamma] emitters in the therapy of neointimal hyperplasia in human coronary arteries.
Ariste has completed pre-clinical models demonstrating proof-of-concept using ePTFE grafts coated with rapamycin and has achieved a significant reduction in neointimal hyperplasia, or scarring within the graft.
When bound, SBCV-030 locally prevents platelet binding to the exposed collagen and the subsequent platelet activation, which can lead to thrombus formation acutely and neointimal hyperplasia chronically.
The rapid elimination of the polymer with the sustained anti-inflammatory and anti-restenotic drug six months beyond the presence of the polymer was designed to allow normal healing while providing effective suppression of neointimal hyperplasia.
Sirolimus acts by binding to FK506 binding protein-12 and inhibits restenosis cascade by blocking inflammation, neointimal hyperplasia, collagen synthesis and migration of smooth muscle cells (24).
The Combo Stent has demonstrated significantly lower neointimal hyperplasia, improved endothelial coverage relative to commercially available drug-eluting stents and lower presence of inflammation and foreign body reaction in multiple pre-clinical studies," said Renu Virmani, M.
Drug-eluting stents have been proposed as an alternative approach to decrease neointimal hyperplasia.
Increased compliance presumably will reduce neointimal hyperplasia and increase patency.