The aim of this study was to investigate the possible inhibitory effects of zoledronic acid (ZA) as an MMP inhibitor on neointimal hyperplasia
in a rabbit-model of carotid anastomosis.
During surgical or interventional vascular procedures, the vulnerable lining of the vessel is injured, which leads to a local cascade of unwanted events, from initial inflammation to delayed neointimal hyperplasia
Paclitaxel stent coating inhibits neointimal hyperplasia
at 4 weeks in a porcine model of coronary restenosis.
Metallic Surface Treatment Using Electrochemical Polishing Decreases Thrombogenicity and Neointimal Hyperplasia
of Coronary Stents.
Dosimetric considerations for catheter-based [beta] and [gamma] emitters in the therapy of neointimal hyperplasia
in human coronary arteries.
Ariste has completed pre-clinical models demonstrating proof-of-concept using ePTFE grafts coated with rapamycin and has achieved a significant reduction in neointimal hyperplasia
, or scarring within the graft.
When bound, SBCV-030 locally prevents platelet binding to the exposed collagen and the subsequent platelet activation, which can lead to thrombus formation acutely and neointimal hyperplasia
The rapid elimination of the polymer with the sustained anti-inflammatory and anti-restenotic drug six months beyond the presence of the polymer was designed to allow normal healing while providing effective suppression of neointimal hyperplasia
Sirolimus acts by binding to FK506 binding protein-12 and inhibits restenosis cascade by blocking inflammation, neointimal hyperplasia
, collagen synthesis and migration of smooth muscle cells (24).
The Combo Stent has demonstrated significantly lower neointimal hyperplasia
, improved endothelial coverage relative to commercially available drug-eluting stents and lower presence of inflammation and foreign body reaction in multiple pre-clinical studies," said Renu Virmani, M.
Drug-eluting stents have been proposed as an alternative approach to decrease neointimal hyperplasia
Increased compliance presumably will reduce neointimal hyperplasia
and increase patency.