Physiologic process in which immature erythrocytes are selectively hemolyzed, resulting in adaptation to a new environment in which erythrocyte mass is excessive; discovered in studies of patients with space-flight-related anemia.
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The loss of red blood cell mass is due to a physiological process called neocytolysis, in which immature blood cells are selectively hemolyzed because of reductions in the plasma erythropoietin levels (48), (49).