In keeping with this conclusion is the process occurring upon transition of lowlanders from hypoxia to normoxia (for instance, mountain climbers returning to sea level after high altitude acclimatization), which consists of a decrease of EPO plasma level and a fast reduction of erythrocyte mass through neocytolysis, i.
Neocytolysis has been observed in healthy subjects after return from high altitude to sea level and is involved also in anemias associated to reduced production of EPO, for instance in renal diseases.
In subjects exposed to conditions triggering neocytolysis, beside the dramatic reduction of young RBCs counts, changes in neocytes membrane components have been observed contributing to a "senescent-like" phenotype and likely targeting them to macrophage phagocytosis.
Neocytolysis is involved also in anemias associated to reduced production of EPO, for instance in renal diseases (11).
After hypoxia exposure, neocytolysis could eliminate those red cells, that, after a maturation from erythroid precursors under low oxygen partial pressure condition, could have phenotypic and functional properties not appropriate to a normoxic environment.
3) And does EPO's decrease, occurring during deacclimatisation, the main cause triggering neocytolysis, as the abrogation of neocytolysis in vivo by EPO administration seems to suggest (8)?
Studying neocytolysis in a number of physiological and pathological systems may be beneficial in the treatment of some particular blood diseases, and furthermore it may be also helpful to pave the way for the biochemical identification of hypothetical "survival factors" acting on RBCs.
In case of EPO doping neocytolysis has not been studied, but the prediction of the theory is that, since this process is strictly related to EPO fluctuation, neocytes of athletes would be doomed to destruction after EPO withdrawal.
Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass.
Red blood cell senescence and neocytolysis in humans after high altitude acclimatization.