formation from predifferentiated human adipose derived stem cells in vivo .
Caption: FIGURE 3: Sagittal and coronal T2-weighted MRI of left knee joint illustrating well repaired previous defective area with almost isointense, firmly integrated neocartilage
formation at similar height to the surrounding cartilage without significant BME and healthy appearing subchondral bone at dorsomedial femoral condyle (6 months postoperatively).
NeoCart is an autologous neocartilage
tissue implant that utilizes the patient's own cells to regenerate cartilage in patients suffering from cartilage lesions in the knec.
As the beads degrade, growth factor is released to cells at the interior and exterior of the sheet, providing more uniform cell differentiation into neocartilage
The sheet with sparsely crosslinked microspheres grew into the thickest and most resilient neocartilage
Zimmer, along with ISTO Technologies, also announced the start of its clinical trial for Neocartilage
, a living tissue-engineered graft under investigation as a therapy for knee problems.
The company says the award will help fund the development of a tissue-engineered neocartilage
allograft for the surgical repair of articular cartilage.