neoblast


Also found in: Dictionary, Encyclopedia.

neoblast

an undifferentiated cell associated with the formation of new tissue after damage or wounding.
References in periodicals archive ?
In uninjured planaria, neoblasts are distributed throughout the parenchyma (mesenchyme), and only mitotic cells serve as the source of replacement cells during tissue renewal (Newmark, 2007).
For instance, mortalin was shown to be constitutively expressed in planarian neoblasts, and its experimental silencing resulted in inability to regenerate and maintain the normal cell turnover (Conte et al.
Histological investigations have suggested that the remarkable size of these hyperplasic ovaries versus normal ovaries is due to a greater proliferation of neoblasts transforming into oogonia (Gremigni and Banchetti, 1972; Benazzi, 1974).
The ability to follow individual neoblasts opens the door to uncovering the molecular cues that help planarian stem cells navigate to the site of injury and ultimately may allow scientists to provide therapeutic stem cells with guideposts to their correct destination.
Scattered within the planarian body, neoblasts apparently remain in an unspecialized, stem cell state, which enables them to differentiate into any cell type.
Whereas most adult stem cells in mammals have a limited set of possible fates-blood stem cells can give rise only to various types of blood cells, for example--planarian neoblasts can turn into any cell in the worm's body under the right circumstances.
In the planarian flatworm Schmidtea mediterranea, certain dividing cells called neoblasts have long been identified as essential for the regeneration that repairs the worm's tissues.
Evidence that neoblasts are totipotent stem cells and the source of blastema cells.
The anatomy and histology of bud-formation in the serpulid Filograna implexa, together with some cytological observations on the nuclei of the neoblasts.