The company has four franchises in various stages of clinical and pre-clinical development: HPV-associated cancers, prostate cancer, neoantigen
therapy, and hotspot mutation therapy.
One of the key topics which will be spoken about at the conference will be Neoantigen
in personalized Cancer Immunotherapy.
Specifically, the quality and fitness of neoantigens
--tumor-specific mutated peptides on the surface of cancer cells--can influence a patient's response to immune checkpoint inhibitors, and mathematical models of neoantigen
fitness can serve as biomarkers for response to immunotherapy, according to investigators of two separate but related studies published in Nature.
NOUS-209 has the potential to be the first neoantigen
off-the-shelf cancer vaccine tested in the clinic.
Combination treatments were also observed to induce strong and broad neoantigen
specific immune response.
QS-21 Stimulon is currently being used in combination with Agenus' neoantigen
vaccine, AutoSynVax, now in a Phase 1 clinical trial in cancer.
formation and clastogenic action of hydrochlorofluorocarbons-123 and perchloroethylene in human MCL-5 cells.
16,19) There is evidence across different tumor types that mutational signatures, neoantigen
burden, and expression of other checkpoint inhibitors may predict response to immunotherapies.
Wu, "Personal neoantigen
cancer vaccines: the momentum builds," Oncoimmunology, vol.
PhosImmunes groundbreaking neoantigen
assets significantly expand Agenuss current efforts, and present exciting near-term opportunities for new products and partnerships, said Garo Armen, Agenuss chairman and chief executive officer, in a statement.
I am focused on methods combining immunohistochemical analysis of the tumour microenvironment, tumour sequencing and neoantigen
prediction, and transcriptional signatures of response.
proposed that radiotherapy induces neoantigen
formation, which starts a T-cell response months to years after exposure, stimulating the production of transforming growth factor (TGF-b).