neoadjuvant chemotherapy


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neoadjuvant chemotherapy

Chemotherapy given before cancer surgery with the hope that it will shrink the tumour, resulting in a procedure that is less drastic and has clearer margins.

Indications
Breast, colorectal, lung cancers.

Adverse effects
Nausea, vomiting, hair loss, fatigue, oral ulcers, infection, anaemia, increased bleeding.

neoadjuvant chemotherapy

Induction chemotherapy, neoadjuvant therapy, preemptive chemotherapy, primary chemotherapy Oncology 1. The use of chemotherapy on solid–ie, non-hematopoietic neoplasms–eg, osteosarcomas, anal cancer, head&neck cancer; NC is used in Pts with clinically resectable but locally advanced disease that is not amenable to complete eradication surgery or RT; agents used in NC include cisplatin, 5-FU, vinblastine, and the M-VAC 'cocktail.' See Neoadjuvant therapy. Cf Induction therapy.

Neoadjuvant chemotherapy

Treatment of the tumor with drugs before surgery to reduce the size of the tumor.
Mentioned in: Neuroblastoma
References in periodicals archive ?
Neoadjuvant chemotherapy in advanced penile carcinoma.
Our first diagnosis was ovarian cancer; therefore, three cycles of neoadjuvant chemotherapy with Taxol 175 mg/[m.
Profiling of triple-negative breast cancers after neoadjuvant chemotherapy identifies targetable molecular alterations in treatment-refractory residual disease.
When and how do I use neoadjuvant chemotherapy for breast cancer?
Lymph node involvement after neoadjuvant chemotherapy is an important predictor of survival with favorable outcome for N0 and unfavorable outcome for N3.
In stratified analyses, patients with leptin-positive tumors derived little survival benefit from neoadjuvant chemotherapy, whereas those with leptin-negative tumors fared considerably better if they received this therapy (indeed, about as well as the positive group).
Our study suggests a potential wider role for neoadjuvant chemotherapy in management of stage IV ovarian cancer," Dr.
Controversy remains over whether staging SLNB should be performed before or after neoadjuvant chemotherapy [32].
Sinusoidal obstruction syndrome is a major feature of hepatic lesions associated with oxaliplatin neoadjuvant chemotherapy for liver colorectal metastases.
Neoadjuvant chemotherapy is indicated in the treatment of rhabdomyosarcoma because, unlike most sarcomas, high response rates are seen in this subtype (8).
The addition of trastuzumab to neoadjuvant chemotherapy shows extremely positive benefits for patients.
No statistically significant survival differences were found between neoadjuvant chemotherapy and neoadjuvant chemotherapy plus radiotherapy (P = 0.