neoadjuvant chemotherapy


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neoadjuvant chemotherapy

Chemotherapy given before cancer surgery with the hope that it will shrink the tumour, resulting in a procedure that is less drastic and has clearer margins.

Indications
Breast, colorectal, lung cancers.

Adverse effects
Nausea, vomiting, hair loss, fatigue, oral ulcers, infection, anaemia, increased bleeding.

neoadjuvant chemotherapy

Induction chemotherapy, neoadjuvant therapy, preemptive chemotherapy, primary chemotherapy Oncology 1. The use of chemotherapy on solid–ie, non-hematopoietic neoplasms–eg, osteosarcomas, anal cancer, head&neck cancer; NC is used in Pts with clinically resectable but locally advanced disease that is not amenable to complete eradication surgery or RT; agents used in NC include cisplatin, 5-FU, vinblastine, and the M-VAC 'cocktail.' See Neoadjuvant therapy. Cf Induction therapy.

Neoadjuvant chemotherapy

Treatment of the tumor with drugs before surgery to reduce the size of the tumor.
Mentioned in: Neuroblastoma
References in periodicals archive ?
Neoadjuvant chemotherapy and/or radiotherapy may be considered for LRCC; however, little evidence is available due to a lack of prospective trials.
How often does neoadjuvant chemotherapy avoid axillary dissection in patients with histologically confirmed nodal metastases?
Pathologic downstaging is a surrogate marker for efficacy and increased survival following neoadjuvant chemotherapy and radical cystectomy for muscle-invasive urothelial bladder cancer.
The addition of trastuzumab to the neoadjuvant chemotherapy significantly improved the pCR rate.
To find out whether Ki-67 mRNA expression has a relationship with clinical response to neoadjuvant chemotherapy in breast cancer, we used bivariate analysis, which can be seen in Table 3.
Rea, "Neoadjuvant Chemotherapy in Triple Negative Breast Cancer: An Observational Study," Oncology Research : Featuring Preclinical and Clinical Cancer Therapeutics, vol.
Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution.
The long-term efficacy of neoadjuvant chemotherapy followed by radical hysterectomy compared with radical surgery alone or concurrent chemoradiotherapy on locally advanced-stage cervical cancer.
Results: The results showed that among the 20 patients who underwent neoadjuvant chemotherapy no one had complete response, 55% had partial response, 35% had stable disease, and 2 had progressive disease and were advised palliative radiotherapy only.
"As Principal Investigator for the Phase Ib dose-escalation OVATION 1 study evaluating patients newly diagnosed with Stage III/IV ovarian cancer and treated with four different doses of GEN-1, in combination with neoadjuvant chemotherapy, I was encouraged by this promising data.
However, there is no published data comparing treatment by neoadjuvant chemotherapy or hypofractionation with standard concomitant chemoradiation.
Neoadjuvant chemotherapy is given before local advanced breast cancer surgery.