nelfinavir


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Related to nelfinavir: saquinavir, ritonavir

nelfinavir

 [nel-fin´ah-vir]
an HIV protease inhibitor used as the mesylate salt in treatment of human immuno deficiency virus infection and acquired immunodeficiency syndrome; administered orally.

nelfinavir

(nĕl-fĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its mesylate, often with other drugs, to suppress the replication of HIV.

nelfinavir

A potent HIV protease inhibitor, which is combined with reverse transcriptase inhibitors—e.g., Retrovir (AZT), zidovudine and Epivir (3TC, lamivudine)—acting at late stages in the HIV life cycle.
 
Side effects
Diarrhoea, 20%, increased liver function tests (LFTs), lipodystrophy.
 
Contraindicated drugs
Nelfinavir inhibits the cytochrome P-450 system, precluding co-administration of agents (e.g., amiodarone, astemizole, cisapride, ergot derivatives, midazolam, quinidine, rifampin, terfenadine, triazolam) which are metabolised by the P-450 system.

nelfinavir

Viracept® AIDS A potent HIV protease inhibitor, used with reverse transcriptase inhibitors–eg, Retrovir–AZT, zidovudine and Epivir–3TC, lamivudine; it acts at late stages in the viral life cycle Side effects Diarrhea–20%, ↑ LFTs, lipodystrophy. See AIDS, Antiretroviral, HIV, Protease inhibitors. Cf Reverse transcriptase inhibitor.

nelfinavir

A protease inhibitor drug used in combination with other antiretroviral drugs to treat HIV infections. The drug is on the WHO official list. A brand name is Viracept.
References in periodicals archive ?
de Hoon, "Simultaneous determination of 8 HIV protease inhibitors in human plasma by isocratic high-performance liquid chromatography with combined use of UV and fluorescence detection: amprenavir, indinavir, atazanavir, ritonavir, lopinavir, saquinavir, nelfinavir and M8-nelfinavir metabolite," Journal of Chromatography B, vol.
(b) Old HAART: triple combination antiretroviral regimens containing indinavir, saquinavir, fosamprenavir, nelfinavir, or nevirapine.
Most existing treatments for HER2-positive breast cancer focus on targeting HER2 itself, so one possible advantage of nelfinavir is that it could inhibit cancer cells that have mutated to escape other drugs.
Patients failing previous PI-based HAART were treated with a saquinavir-based regimen, paired either with ritonavir or nelfinavir. In addition, patients received delavirdine with or without adefovir.
Major Finding: Of 25 medications tested, 16 were found to inhibit the metabolism of 17R Those with the strongest inhibitory effects were the asthma drug montelukast, and the protease inhibitors nelfinavir and ritonavir, which were associated with 90%-100% inhibition of 17P.
Ante esta situacion, ademas de las medidas preventivas como la utilizacion del condon y la transfusion de sangre proviente de donadores sanos, se han realizado avances en el tratamiento de la enfermedad, gracias a la creacion de medicamentos antirtrovirales, como zidouvidna, didanosina, zalcibatina, estavudina, lamivudina, abacir, zialgen, nevirapina, delavirdina, efavirenz, indinavir, ritonavir, saquinavir y nelfinavir.
Indinavir and saquinavir, and nelfinavir and atazanvir, were used in 5% and 2%, respectively, of private sector regimens.
Virologic and immunologic parameters in patients participating in antenatal cohort, Canada* CD4 count, cells/ Viral load, Antiretroviral Patient Age, y [mm.sup.3] RNA copies/mL treatment TV721 33.2 210 164 AZT-3TC-NVP TV725 30.1 816 739 None TV749 34.1 198 23,369 AZT-3TC-NFV TV919 34.0 420 1,910 AZT-3TC-NFV * AZT, zidovudine; 3TC, lamivudine; NVP, nevirapine; NFV, nelfinavir.
Em agosto de 2001, o Ministerio da Saude ameacou decretar o licenciamento compulsorio do nelfinavir, fabricado pela Roche.
In 381 most of our patients were on a nelfinavir regimen or an efavirenz regimen, and we saw no response difference between the two (Table 1).
FDA-Approved Antiretroviral Agents Nucleoside RTIs Nonnucleoside RTIs Protease inhibitors abacavir (ABC) delavirdine (DLV) atazanavir (ATV) didanosine (ddl) efavirenz (EFZ) darunavir (DRV) emtricitabine (FTC) etravirine (ETV) fosamprenavir (Fos-APV) lamivudine (3TC) nevirapine (NVP) indinavir (IDV) stavudine (d4T) lopinavir/r (LPV/r) zidovudine (ZDV) nelfinavir (NFV) ritonavir (RTV) saquinavir (SQV) tipranavir (TPV) Nucleotide RTI Integrase inhibitor Fusion inhibitor tenofovir DF (TDF) raltegravir (RAL) enfuvirtide (T-20) CCR5 antagonist maraviroc (MVC) Notes: Six fixed-dose combinations are approved by the Food and Drug Administration.
However, efavirenz, nelfinavir, didanosine, nevirapine, kaletra, indinavir also were used in combinations (Table 2).