nelfinavir


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Related to nelfinavir: saquinavir, ritonavir

nelfinavir

 [nel-fin´ah-vir]
an HIV protease inhibitor used as the mesylate salt in treatment of human immuno deficiency virus infection and acquired immunodeficiency syndrome; administered orally.

nelfinavir

/nel·fin·a·vir/ (nel-fin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the mesylate salt in the treatment of HIV infection.

nelfinavir

(nĕl-fĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its mesylate, often with other drugs, to suppress the replication of HIV.

nelfinavir

an antiviral.
indications It is used alone or in combination with other drugs to treat HIV.
contraindication Known hypersensitivity to protease inhibitors prohibits its use.
adverse effects Life-threatening effects include anemia, leukopenia, thrombocytopenia, and hemoglobin abnormalities. Other adverse effects include anorexia, dyspepsia, headache, asthenia, poor concentration, dermatitis, pain, bleeding, hypoglycemia, and hyperlipidemia. Common side effects include diarrhea, flatulence, and rash.

nelfinavir

A potent HIV protease inhibitor, which is combined with reverse transcriptase inhibitors—e.g., Retrovir (AZT), zidovudine and Epivir (3TC, lamivudine)—acting at late stages in the HIV life cycle.
 
Side effects
Diarrhoea, 20%, increased liver function tests (LFTs), lipodystrophy.
 
Contraindicated drugs
Nelfinavir inhibits the cytochrome P-450 system, precluding co-administration of agents (e.g., amiodarone, astemizole, cisapride, ergot derivatives, midazolam, quinidine, rifampin, terfenadine, triazolam) which are metabolised by the P-450 system.

nelfinavir

Viracept® AIDS A potent HIV protease inhibitor, used with reverse transcriptase inhibitors–eg, Retrovir–AZT, zidovudine and Epivir–3TC, lamivudine; it acts at late stages in the viral life cycle Side effects Diarrhea–20%, ↑ LFTs, lipodystrophy. See AIDS, Antiretroviral, HIV, Protease inhibitors. Cf Reverse transcriptase inhibitor.

nelfinavir

A protease inhibitor drug used in combination with other antiretroviral drugs to treat HIV infections. The drug is on the WHO official list. A brand name is Viracept.
References in periodicals archive ?
1093/jnci/djs396) "Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir.
Unboosted atazanavir has been shown to have similar efficacy to nelfinavir and efavirenz in three clinical studies [36-38].
Indinavir monohydrate (free base), nelfinavir mesylate, ritonavir, and saquinavir mesylate were gifts from Merck Research Laboratories, Agouron Pharmaceutical Inc.
At A Glance -- According to 48-week data from SOLO and NEAT Phase III trials: The frequency of moderate to severe drug-related diarrhea was significantly lower (5 percent to 10 percent of treatment-naive HIV infected adults) treated with the PI LEXIVA compared to 18 percent of patients taking nelfinavir (NFV).
The first-generation discussion was the nelfinavir vs.
Importantly, 3 patients in the Kaletra arm and 3 patients in the nelfinavir arm experienced new AIDS-defining clinical events despite having viral loads below the limit of quantification.
If nelfinavir replaced indinavir in the regimen, adjustment of dose relative to food intake must be made because food increases absorption of nelfinavir.
July 8 /PRNewswire/ -- The protease inhibitor (PI) LEXIVA(R) (fosamprenavir calcium) dosed with ritonavir (LEXIVA/r) once-daily (QD) as part of a first-line ART regimen provided antiviral suppression that was comparable in this single study to the PI nelfinavir (NFV) dosed twice-daily (BID), according to 48-week data from the SOLO trial published in the July 23 issue of AIDS.
FDA Pregnancy Categories of Antiretroviral Drugs Nucleoside Nonnucleoside Reverse Reverse Transcriptase Transcriptase Protease Category Inhibitors Inhibitors Inhibitors B didanosine (ddl) atazanavir emtricitabine nelfinavir tenofovir ritonavir saquinavir C abacavir efavirenz amprenavir lamivudine (3TC) nevirapine indinavir stavudine (d4T) lopinavir/ritonavir zalcitabine (ddC) zidovudine (AZT) D Fusion Miscellaneous Category Inhibitors Agents B enfuvirtide C D hydroxyurea Note: No antiretroviral agents in pregnancy category A or X.
One group of 16 women received only zidovudine, and another 16 women received triple therapy with zidovudine, lamivudine, and nelfinavir.
centers were randomly assigned to receive either PREVEON 60 mg (n=107) or 120 mg (n=104) along with a combination of either nelfinavir and saquinavir or of a nucleoside reverse transcriptase inhibitor (AZT, 3TC or d4T) plus nelfinavir or saquinavir.