Densen, "Complement deficiency states and infection: epidemiology, pathogenesis, and consequences of neisserial
and other infections in an immune deficiency," Medicine, vol.
By flow cytometry, the outbreak strain had low expression of factor H binding protein and low binding with antisera to the Neisserial
heparin binding antigen included in Bexsero (Table) (7).
MenB-4C consists of three recombinant proteins (neisserial
adhesion A [NadA], factor H binding protein [FHbp] fusion protein, and neisserial
heparin binding antigen [NHBA] fusion protein) and outer membrane vesicles (OMVs) containing outer membrane protein PorA serosubtype P1.4.
Bexsero[R] contains four immunodominant antigens: fHbp, PorA, NadA and neisserial
heparin binding antigen (NHBA) (Bai et al, 2011).
binding to CEACAMI arrests the activation and proliferation of CD4+ T lymphocytes," Nature Immunology, vol.
Other known genes in this pathway, however, are absent from the sequenced neisserial
Because serogroup distributions vary by country, the vaccine in the United Kingdom protects against group C Neisserial
meningitidis, while the U.S.
Deficiency of the complement component, C3, leads to repeated sinopulmonary infections similar to agammaglobulinemia, while deficiencies in the terminal complement components (C6, C7, C8, C9) result in recurrent systemic infections or meningitis with neisserial
Wetzler, "Cutting edge: immune stimulation by neisserial
porins is toll-like receptor 2 and MyD88 dependent, " The Journal of Immunology, vol.
Bexsero includes 4 different components: an FHbp of variant 1 (subfamily B); a Neisseria adhesion A protein (NadA); a neisserial
heparin-binding antigen (NhbA); and outer membrane vesicles from a serogroup B strain containing PorA P1.4 (19).
MenB-4C consists of three recombinant proteins (Neisserial
adhesin A [NadA], factor H binding protein [FHbp] fusion protein, and Neisserial
Heparin Binding Antigen [NHBA] fusion protein), and outer membrane vesicles (OMVs) containing outer membrane protein PorA serosubtype P1.4.