negative stain


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neg·a·tive stain

stain forming an opaque or colored background against which the object to be demonstrated appears as a translucent or colorless area; in electron microscopy, an electron opaque material, such as phosphotungstic acid or sodium phosphotungstate, is used to give detail to surface structure.

neg·a·tive stain

(neg'ă-tiv stān)
Stain forming an opaque or colored background against which the object to be demonstrated appears as a translucent or colorless area; in electron microscopy, an electron opaque material, such as phosphotungstic acid or sodium phosphotungstate, is used to give detail as to surface structure.
References in periodicals archive ?
However, the current situation is likely to leave a very negative stain on Turkish politics and even on society as a whole.
Thin section and negative stain electron microscopy (EM) examination of viruses grown in cultured cells have been instrumental in determining an etiologic agent in numerous disease outbreaks caused by previously unknown viruses.
The liposomes and their complexes with PS/ON were also characterized by using a negative stain electron microscope.
The evaluation of different heavy metal salts for negative staining showed that the quality of EM as a diagnostic method does not depend on the negative stain used.
Negative stain electron microscopy was performed by using cell culture supernatant.
In this case the absence of lymphoglandular bodies and the presence of large clusters of cohesive cells and a negative stain for LCA ruled out a lymphoma.
Because of this limited sensitivity, a negative stain should not be considered informative (negative predictive value = 40%), but because of high specificity, a positive stain does strongly favor malignancy (positive predictive value = 98%).
After a simple and fast negative stain preparation, the undirected, "open view" of electron microscopy allows rapid morphologic identification and differential diagnosis of different agents contained in the specimen.
Rotavirus infections were diagnosed by negative stain electron microscopy.
A negative stain preparation may be made and a result could be obtained within 5 minutes of the specimen's arrival in the EM laboratory.
Previous reports of CSH have also demonstrated negative stain for [kappa] or [lambda] in histiocytes.