negative selection


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negative selection

The process by which immature T lymphocytes (thymocytes) with receptors for autoantigens are destroyed in the thymus. It is part of the mechanism that prevents autoimmune diseases.
See: autoimmunity
See also: selection
References in periodicals archive ?
According to negative selection and network compression operators, redundant and similar food sources should be eliminated.
We conducted highly stringent negative selections against the immobilization substrate and two closely related molecules: 6-amino-3-ethyl methyl uracil and 1-methyl uracil.
The system is basically an intrusion detection system which uses detectors generated by genetic algorithm combined with deterministic-crowding niching technique, applied on NSL-KDD IDS test data set under the scope of negative selection theory.
In negative selection algorithms, the greedy and variable-length detector generation methods optimize the detector set during the generation process [19][20].
Higher liquidity should lead to better price but, as is the case with systematic negative selection, this relationship is not always true.
Tregs are critical in the suppression of autoreactive lymphocytes that have escaped elimination through negative selection in the thymus (Cupedo et al.
Values of FR are all positive, but negative selection is indicated by values less than unity and positive [TABULAR DATA FOR TABLE 4 OMITTED] selection by values greater than unity; the value 1 represents no selection.
Alternatively, there may be negative selection of immigrants into enclaves: those immigrants with lower unobservable skills may be more likely to join an enclave community.
While cTECs are critical at the early stages of T cell development, mTECs play a pivotal role in negative selection of self-reactive thymocytes and the generation of Foxp3+ regulatory T (Treg) cells.
These important algorithms are clonal selection algorithm and negative selection algorithm.
Operators of dark pools in Europe are predicted to spend a[logical not]20.09 million on anti-gaming and surveillance logic by 2012, rising from a[logical not]17.11 million this year, to alleviate buy-side fears about negative selection and gaming.