Negative inotropic agent | definition of negative inotropic agent by Medical dictionary
negative inotropic agent
negative inotropic agent Any agent, including beta-blockers (e.g., metoprolol) or calcium channel blockers (e.g., diltiazem, verapamil), used to manage congestive heart failure caused by pure diastolic dysfunction, as such agents reduce cardiac contractility.
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References in periodicals archive
Therefore, negative inotropic agents may result in a suppression of atrial contractility and decreased LAA flow velocities with AF.
Decreased left atrial appendage flow velocity with atrial fibrillation caused by negative inotropic agents. Circ J 2003; 67: 277-8.