p<1 indicate that the binding of the ligand molecules have less affinity for binding to the other sites on the biomolecule, can be appoint negative cooperativity
. p=1 demonstrates the noncooperative interaction.
These sites exhibit negative cooperativity and, as a result, only one molecule of [T.sub.4] is bound to TTR under physiological conditions (Ferguson et al.
These weaker interactions with the second binding site are consistent with the negative cooperativity between these sites that is observed with [T.sub.4] (Ferguson et al.
Negative cooperativity in the binding of thyroxine to human serum prealbumin.
While many complex reaction networks do not satisfy the MM assumptions and hence do not exhibition M-M behavior in their concentration profiles, the M-W-C equation has limitations such as the inability to portray negative cooperativity
among multiple enzyme-substrate systems.
In other words, negative cooperativity
between the binding sites should appear for these substrates.
(16,17) Whether this alanine and valine rich segment can influence ErbB2 dimer stability or induce lateral signalling by negative cooperativity with EGF remains to be seen.
Besides density of EGFR is important in negative cooperativity and lateral signalling.
argentatum, negative cooperativity inhibits the chain transfer reaction across a wide range of FPP concentrations, a property possessed in far less degree by H.
argentatum rubber transferase, with its intrinsic property of negative cooperativity, is more likely to produce high molecular weight rubber in a wide range of genetic backgrounds (i.e., in other species) than the rubber transferases from either H.
The strong negative cooperativity, obtained from this powerfull model, were suggested the denaturation of HSA by toxic Lanthanide ions.
p<1 or p>1 indicate positive or negative cooperativity of macromolecule for binding with ligand respectively; p = 1 indicates that the binding is non-cooperative [7-9].