negative cooperativity

neg·a·tive co·op·er·a·tiv·i·ty

cooperativity in which successive ligand molecules appear to bind with decreasing affinity.
References in periodicals archive ?
These sites exhibit negative cooperativity and, as a result, only one molecule of [T.
These weaker interactions with the second binding site are consistent with the negative cooperativity between these sites that is observed with [T.
Negative cooperativity in the binding of thyroxine to human serum prealbumin.
While many complex reaction networks do not satisfy the MM assumptions and hence do not exhibition M-M behavior in their concentration profiles, the M-W-C equation has limitations such as the inability to portray negative cooperativity among multiple enzyme-substrate systems.
16,17) Whether this alanine and valine rich segment can influence ErbB2 dimer stability or induce lateral signalling by negative cooperativity with EGF remains to be seen.
Besides density of EGFR is important in negative cooperativity and lateral signalling.
argentatum, negative cooperativity inhibits the chain transfer reaction across a wide range of FPP concentrations, a property possessed in far less degree by H.
argentatum rubber transferase, with its intrinsic property of negative cooperativity, is more likely to produce high molecular weight rubber in a wide range of genetic backgrounds (i.