nedocromil sodium

Also found in: Dictionary.
Related to nedocromil sodium: imipramine, cromolyn sodium, Tilade

nedocromil sodium

the sodium salt of nedocromil, administered topically to the conjunctiva in the treatment of allergic conjunctivitis.

mast cell stabilizers

Prophylactic drugs used to treat allergic conjunctivitis, vernal conjunctivitis, giant pupillary conjunctivitis, superior limbic keratoconjunctivitis. They act by stabilizing the membranes of mast cells thus preventing the release of histamine. Common agents are sodium cromoglicate (cromolyn sodium), lodoxamide, nedocromil sodium, olopatadine hydrochloride and pemirolast potassium. See antihistamine; hypersensitivity.

nedocromil sodium (ned´ōkrō´mil),

n brand name: Tilade;
drug class: antiasthmatic, mast cell stabilizer;
action: stabilizes the membrane of the sensitized mast cell, preventing release of chemical mediators after an antigen-IgE interaction;
use: prophylaxis only in reversible obstructive airway diseases such as asthma.
References in periodicals archive ?
Nedocromil sodium has also been shown to be of potential use in reducing high-dose inhaled steroid use.
Jones P and the Nedocromil Sodium Quality of Life Study Group.
Cromolyn sodium and nedocromil sodium are non-steroidal treatments that may also be inhaled and used as "controller" medication rather than for treating symptoms once they've developed.
Is nedocromil sodium an effective prophylaxis for EIB in children?
13-16) The logic of such a treatment might be questioned since sodium cromoglicate is not considered to have any constitutive anti-inflammatory activity; the removal of the stimulus to inflammation should help and better results might be obtained with other mast cell stabilisers/anti-eosinophil drugs such as lodoxamide or nedocromil sodium (both available to AS optometrists).
Nedocromil sodium exerts its anti-inflammatory and antiasthmatic effect by inhibiting the activation and activity of multiple inflammatory cells, including mast cells, eosinophils, airway epithelial cells and sensory neurons.
Nedocromil sodium versus sodium cromoglycate for preventing exercise-induced bronchoconstriction in asthmatics.
The multicenter Childhood Asthma Management Program (CAMP) found no differences in final height among randomized groups of 311 children on budesonide, 312 on nedocromil sodium (Tilade), and 418 on matching placebos.
Nedocromil Sodium - Nedocromil is marketed as Tilade in an MDI formulation.
The clinical efficacy of inhaled nedocromil sodium (Tilade) in the treatment of asthma.
Although inhaled corticosteroids are first-line anti-inflammatory agents and acceptable for primary therapy of moderate asthma in children, the antiasthmatic prophylactic agents cromolyn sodium, nedocromil sodium, and leukotriene modifiers may be used as an initial choice for long-term control therapy in mild persistent asthma (step 2 therapy) with children, because these medications have excellent safety profiles.