Nedocromil sodium has also been shown to be of potential use in reducing high-dose inhaled steroid use.
When nedocromil sodium in a four-times-daily dose was added to current therapy in stable, mild asthmatic children in placebo comparisons, there was significant improvement in daily peak expiratory flow and a reduction in daily bronchodilator use.
Jones P and the Nedocromil Sodium
Quality of Life Study Group.
Cromolyn sodium and nedocromil sodium
are non-steroidal treatments that may also be inhaled and used as "controller" medication rather than for treating symptoms once they've developed.
ALOCRIL(TM) is administered in a sterile, topical solution containing 2% nedocromil sodium.
In an environmental study (N = 79), 37 percent of the subjects participating reported experiencing relief from symptoms within two minutes of applying nedocromil sodium ophthalmic solution 2% topically; fully 77 percent achieved control over their symptoms within 15 minutes.
- Nedocromil is marketed as Tilade in an MDI formulation.
Although inhaled corticosteroids are first-line anti-inflammatory agents and acceptable for primary therapy of moderate asthma in children, the antiasthmatic prophylactic agents cromolyn sodium, nedocromil sodium
, and leukotriene modifiers may be used as an initial choice for long-term control therapy in mild persistent asthma (step 2 therapy) with children, because these medications have excellent safety profiles.
In addition to the opening, Rhone-Poulenc Rorer announced that it would be taking an option on an adjacent 4-hectare plot and would also be investing US$15 million in the first and original facility at the site (completed in 1993) to create a dual purpose plant for nedocromil sodium and sodium cromoglycate.
Bernard Dubois, president of Worldwide Industrial Operations for Rhone-Poulenc Rorer, commented that, "the opening of this new facility along with further investment to improve the flexibility of the nedocromil sodium plant and our commitment to the adjacent 4-hectares sends a clear message of our long-term commitment to Singapore as a manufacturing base for active pharmaceutical ingredients.
Later, the alliance will expand to include Fisons' Opticrom(R) (4 percent cromolyn sodium ophthalmic solution, USP) and nedocromil sodium ophthalmic solution.
Fisons and Allergan will also co-develop and co-promote Fisons' nedocromil sodium ophthalmic solution, which will be launched in the U.