More recently, other posttranslational modifications of histones have been described such as
neddylation, sumoylation, glycosylation, phosphorylation, poly-ADP ribosylation, and ubiquitination [2].
Some rare and unconventional PTMs, such as glypiation,
neddylation, siderophorylation, AMPylation, and cholesteroylation, are also known to influence protein structure and function [27].
Li, "MLN4924 suppresses
neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma," Oncotarget, vol.
CBS9106-induced CRM1 degradation is mediated by cullin ring ligase activity and the
neddylation pathway.
Neddylation is a reversible post-translational protein modification whereby a small ubiquitin like protein (UBL), NEDD8 (neural precursor cell expressed developmentally downregulated protein (8), is attached to substrate proteins through a series of enzymatic reactions.
[Source:RefSeq mRNA;Acc:NM_213801] ENSSSCG00000009425 laccase (multicopper oxidoreductase) domain containing 1 [Source:HGNC Symbol;Acc:26789] ENSSSCG00000009540 ligase IV, DNA, ATP-dependent [Source:HGNC Symbol;Acc:6601] ENSSSCG00000026536 DCN1, defective in cullin
neddylation 1, domain containing 2 [Source:HGNC Symbol;Acc:20328] ENSSSCG00000017142 BAI1-associated protein 2 [Source:HGNC Symbol;Acc:947] ENSSSCG00000017146 ring finger protein 213 [Source:HGNC Symbol;Acc:14539] ENSSSCG00000017169 SEC14-like 1 (S.
P Xirodimas, "Regulation of nucleolar signalling to p53 through
NEDDylation of L11," EMBO Reports, vol.
Neddylation and sumoylation have not been demonstrated to affect p53 stability yet.
The remarkable pleiotropy of CSN is partially explained through its enzymatic activity towards Cullin-RING E3 ubiquitin ligases (CRLs), which are activated by
neddylation and inactivated by CSN-mediated deneddylation.
Expression of this miRNA was shown to promote proliferation by regulation of CAND1 [encoded by cullin-associated and
neddylation dissociated 1 (CAM51)] (49).
Phosphorylation of VACM-1/Cul5 by Protein Kinase A regulates its
neddylation and antiproliferative effect.
It has also been reported that bacteria elicit ROS generation in epithelial cells that inactivate the Ubc12 enzyme, preventing the
neddylation of cullin-1.
