necrotizing vasculitis


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vasculitis

 [vas″ku-li´tis]
inflammation of a blood or lymph vessel; see arteritis, lymphangitis, and phlebitis. Called also angiitis.
Churg-Strauss vasculitis churg-strauss syndrome.
hypersensitivity vasculitis a group of systemic necrotizing vasculitides thought to represent hypersensitivity to an antigenic stimulus, such as a drug, infectious agent, or exogenous or endogenous protein; all disorders in this group involve the small vessels.
necrotizing vasculitis see systemic necrotizing vasculitis.
nodular vasculitis a chronic vasculitis of unknown etiology found predominantly below the knees, especially on the calves in young and middle-aged women, characterized by the presence of painful, reddish blue nodular lesions that may ulcerate, leaving scars, or resorb, leaving atrophic depressions. In the late stages, there is replacement of the subcutaneous fat by fibrosis and atrophy (wucher atrophy).
systemic necrotizing vasculitis any of a group of disorders characterized by inflammation and necrosis of blood vessels, occurring in a broad spectrum of cutaneous and systemic disorders. It includes Churg-Strauss syndrome, polyarteritis nodosa, the various kinds of hypersensitivity vasculitis, and other conditions. Called also necrotizing vasculitis.
References in periodicals archive ?
Necrotizing vasculitis is a distinct subtype of vasculitis with inflammation and fibrinoid necrosis of the vessel wall.
During laparotomy, the omentum was obviously involved, and its histological examination showed necrotizing vasculitis of the venules and palisading granuloma.
Caption: Figure 3: Histopathological examination of the granulomatous mucosa from the ethmoid sinus shows significant necrotizing vasculitis (a) and granulomatous inflammation with multinucleated giant cells (b) (HE staining, x200).
(b) H&E stain x400 reveals acute necrotizing vasculitis; dense neutrophilic inflammatory exudate; and necrosis in vessel wall.
The characteristics which differentiate antineutrophilic cytoplasmic antibody-related vasculitis from small vessel vasculitis include being necrotizing vasculitis, absence of immune complexes (or presence of very few immune complexes) and being related with PR3 and MPO-ANCA.
Granulomatosis with polyangiitis is an uncommon disease and systemic necrotizing vasculitis. (1) Cardiac involvement in GPA can be in the form of silent ischemia in the majority of patients; while in other patients, it may present as conduction abnormalities, pericarditis, granulomatous myocarditis, valvulitis, endocarditis, coronary arteritis, aneurysms, and myocardial infarction.
Diagnosis of Wegener disease is established with biopsy, revealing necrotizing vasculitis in a setting of granulomatous inflammation and the presence of serum antineutrophil cytoplasmic antibodies.
We identified a canine circovirus in the liver of a dog that had necrotizing vasculitis and granulomatous lymphadenitis, both of which are described in PCV2-infected pigs (4).
Update on pathogenic mechanisms of systemic necrotizing vasculitis. Curr Rheumatol Rep.