When it is involving the oral cavity, the most commonly involved sites are tongue, palate, buccal mucosa, gingiva, and pharynx and the differential diagnoses should include squamous cell carcinoma, hematologic malignancy, tuberculosis, other deep fungal infections, oral lesions of Crohn's disease, necrotizing sialometaplasia
of the palate, and chronic traumatic ulcers.
is a condition which mostly arises from palatal minor salivary glands.
We report a rare case of necrotizing sialometaplasia
of the right lateral nasopharynx with extension into the right parapharyngeal space in a 39-year-old man.
The differential diagnosis precluded minor salivary gland tumors, necrotizing sialometaplasia
& ulcers secondary to systemic diseases like HIV, diabetes & blood dyscrasias.
: a practical approach to the diagnosis.
Necrotizing sialometaplasia (NSM) is a benign, self-healing lesion of salivary glands, which represents less than 1% of biopsied oral lesions.
Anneroth and Hansen4 proposed 5 histologic stages in the development and evolution of necrotizing sialometaplasia: infarction, sequestration, ulceration, repair, and healing.
Necrotizing sialometaplasia is a benign, spontaneously healing inflammatory condition.
Necrotizing sialometaplasia is a benign inflammatory process that involves the minor salivary glands, primarily those of the hard palate.
MECs must be distinguished from necrotizing sialometaplasia
, chronic sialadenitis, cystadenoma, cystadenocarcinoma, squamous cell carcinoma, epithelial-myoepithelial carcinoma, clear cell carcinoma (not otherwise specified), and metastatic tumors.
is a benign, self-limited, reactive inflammatory process that involves salivary glands.
(1) In our patient, the differential diagnosis included (1) benign fibrous and neural tumors with secondary ulceration, (2) a specific infection, and (3) perhaps necrotizing sialometaplasia
. Salivary gland tumors, while common in the palate, are not usually found in the midline, although one of the authors (S.O.K.) has seen several during his career.