Kikuchi Fujimoto disease (KFD), otherwise called histiocytic necrotizing lymphadenitis
is an uncommon, idiopathic disease affecting Japanese and east Asian individuals more commonly with a male to female ratio of 1:4.1-5.
Multiple infectious agents can cause necrotizing lymphadenitis
, which may mimic KFD.
Noninfectious causes include histiocytic necrotizing lymphadenitis
which is a benign lymphadenitis, characterized by enlarged lymph nodes with histopathological findings of proliferation of lymphocytes and histiocytes, nuclear debris, and necrotic lesions affecting mainly young women ; systemic lupus erythematosus with lupus lymphadenitis can present with necrotic mediastinal lymph nodes .
In this study, the cytomorphological features observed in the cases were caseating epithelioid granulomas [47.6% (108/227)], granulomatous lymphadenitis [33.9% (77/227)], necrotizing lymphadenitis
[1.8% (4/227)], and necrotizing suppurative lymphadenitis [16.7% (38/227)] of cases.
Treatment of histiocytic necrotizing lymphadenitis
(Kikuchi's disease) with prolonged fever by a single course of methylprednisolone pulse therapy without maintenance therapy: experience with 13 cases.
Kikuchi-Fujimoto disease or Sub-acute necrotizing lymphadenitis
is a benign self-limiting condition.
Kikuchi-Fujimoto Disease (KFD), also known as histiocytic necrotizing lymphadenitis
, was described in Japan, in 1972, by Kikuchi and Fujimoto (1,2) simultaneously.
Cervical subacute necrotizing lymphadenitis
. A New Clinicopathological Entity 1972;20:920-7.
Kang, "Causative agents of Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis
): a meta-analysis," International Journal of Pediatric Otorhinolaryngology, vol.
patterns showed 83.87% (78) AFB positivity.
Granulibacter bethesdensis is an emerging pathogen in patients with CGD that causes fever and necrotizing lymphadenitis
. However, unlike typical CGD organisms, this organism can cause relapse after clinical quiescence.