The patient presented here was one of the rare cases with diffuse necrotizing encephalitis
with lesions disseminated over the periventricular white matter, basal ganglia, thalamus, brainstem and cerebellum without an immunodeficiency syndrome.
Animal studies indicate that active viral replication and necrotizing encephalitis
with diffuse perivascular infiltrates of lymphocytes and maerophages occur in cerebral parenchyma (9,10).
Herpes simplex virus type 1 (HSV-1), in addition to causing recurrent cold sores and corneal infections, may cause a severe necrotizing encephalitis
in children and adults.