necrotic keratinocyte

necrotic keratinocyte

A rounded, pale, pink anucleated keratinocyte, typically seen in the lower epidermis, classically present in lichen planus but also in lupus erythematosus, lichenoid keratosis and graft-versus-host disease.
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Histopathology of the lesion revealed psoriasiform hyperplasia, hyperkeratosis, parakeratosis, spongiosis and few necrotic keratinocytes in upper epidermis.
Necrotic keratinocytes may be seen in the epidermis.
The histopathologic hallmark of PNP is a predominant interface reaction pattern, characterized by basal cell vacuolar degeneration, dyskeratotic and necrotic keratinocytes, and lymphocytic inflammation characterized by lymphocytic exocytosis with either as sprinkling of lymphocytes at the basement membrane zone or a band-like infiltrate in the upper dermis.
Histopathological findings usually show perivascular lymphocytic infiltration, melanophages, vacuolization of the basal layer, and necrotic keratinocytes (4).
A shave biopsy revealed a mild to moderate hyperplastic epidermis with eosinophilic spongiosis and many scattered necrotic keratinocytes (figure 2).
The findings from the erosions revealed a subcorneal cleft made up of necrotic keratinocytes covered by a thick orthokeratotic horny layer at the roof.
The histopathologic differential of HLE includes lesions that display pseudoepitheliomatous hyperplasia in association with varying amounts of squamous atypia and necrotic keratinocytes.
Histology reveals a thinned stratum corneum, dilated follicular infundibula, necrotic keratinocytes, and mixed inflammation in the upper dermis.
Significant dermal edema and necrotic keratinocytes may be seen.
The patient's biopsy revealed necrotic keratinocytes and exocytosis of lymphocytes and was consistent with EM.
To the side of the blister the epidermis showed scattered necrotic keratinocytes in mid-epidermis and at dermoepidermal junction.
Necrotic keratinocytes and focal hyperkeratosis can be noted, along with squamous atypia.