Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis
in a sirtuin-dependent manner Cell Death Differ., 23(1):29-40, 2015.
Oxidative stress induced necroptosis
activation is involved in the pathogenesis of hyperoxic acute lung injury.
: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.
is defined as a spectrum between uncontrolled random cell death and programmed cell death (13,14,15).
Cancer-type-specific crosstalk between autophagy, necroptosis
and apoptosis as a pharmacological target.
Quantification of apoptosis and necroptosis
at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining.
Moreover, autophagy activation is observed in a number of necrotic-like programmed cell death types, including necroptosis
and autosis; however, the contribution of autophagy to these novel death pathways has not been thoroughly analyzed (41).
Among them, the activation of self-reactive lymphocytes and their infiltration in the pancreas, followed by the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-[alpha]), which united with its membrane receptor on the PBC, activate intracellular signaling pathways that end in the induction of proapoptotic mechanisms and, in some cases, cell death through necroptosis
results from oligomerization of mixed lineage kinase domain-like protein (MLKL) , which is initiated by receptor-interacting serine/threonine-protein kinase 3- (RIPK3-) dependent phosphorylation [8, 9].
Wang, "Retinal pigment epithelial cell necroptosis
in response to sodium iodate," Cell Death Discovery, vol.
The HSV R1 protein is involved in evasion of cell death by preventing necroptosis
in human but not mouse cells [129-131].
MTT Assay in the Presence of Caspase Inhibitor (Z-VAD-FMK) and Necroptosis
Inhibitor (Necrostatin-1) and Oxidative Stress Induce Necrosis Inhibitor (IM-54).