necroptosis

necroptosis

A more recent term for regulated cell necrosis, which is carried out by so-called death receptors—e.g., tumour necrosis factor receptor 1, which requires receptor-interacting protein kinase 1 (encoded by RIPK1) and receptor-interacting protein kinase 3 (encoded by RIPK3). Necroptosis requires the active disintegration of mitochondrial, lysosomal and plasma membranes, and it is pathogenetically linked to ischaemic injury, neurodegeneration and viral infection, making the process an attractive therapeutic target in the future. It contrasts to apoptosis (formerly regarded as the only form of programmed cell death to be carried out during development, homeostasis and disease) and to necrosis (which is regarded as an unregulated and uncontrollable process).
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Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process.
regulated cell death, especially apoptosis and necroptosis, are natural barriers that restrict malignant cells from surviving and disseminating.
Grand challenges in cell death and survival: apoptosis vs necroptosis.
It is anticipated that this process is responsible for the CSF aggregates linked to motor neuron destruction, and that this process may stimulate execution of necroptosis in astrocytes, which is selectively destructive to motor neurons.
So their bystander effect on long-term viable myocardial adjacent cells in perinecrotic region could cause probably a kind of successive numerous cell's suicide so that Cx43 would contribute numerous jeopardised cardiomyocytes to undergo apoptosis and/or necroptosis during reperfusion.
Inhibitors of apoptosis, oxidative stress and necroptosis were tested to evaluate their protective effect against stenodactylin cytotoxicity.
Necroptosis was recently discovered as one form of programmed cell death (PCD) that shares characteristics with both necrosis and apoptosis.
The exact mechanism of cell death is not known but proposed mechanism after mechanical trauma is due to necroptosis, apoptosis, autoptosis or due to pyroptosis.
Among specific topics are detecting apoptosis in cell-free systems, analyze cellular necroptosis, the transglutamination of proteins involved in apoptosis, fluorometric methods for detecting mitochondrial membrane permeabilization during apoptosis, the genetic mapping of anti-apoptosis pathways in myoloid progenitor cells, and a reliable method for detecting programmed cell death in yeast.