necroptosis

necroptosis

A more recent term for regulated cell necrosis, which is carried out by so-called death receptors—e.g., tumour necrosis factor receptor 1, which requires receptor-interacting protein kinase 1 (encoded by RIPK1) and receptor-interacting protein kinase 3 (encoded by RIPK3). Necroptosis requires the active disintegration of mitochondrial, lysosomal and plasma membranes, and it is pathogenetically linked to ischaemic injury, neurodegeneration and viral infection, making the process an attractive therapeutic target in the future. It contrasts to apoptosis (formerly regarded as the only form of programmed cell death to be carried out during development, homeostasis and disease) and to necrosis (which is regarded as an unregulated and uncontrollable process).
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Intracellular nicotinamide adenine dinucleotide promotes TNF-induced necroptosis in a sirtuin-dependent manner Cell Death Differ., 23(1):29-40, 2015.
Impairment Induction by Axotomy in Motor Functional and Histological Anterior Horn of Spinal Cord Structure/Induccion del Deterioro por Axotomia en la Estructura Motora Funcional e Histologica del Asta Anterior de la Medula Espinal
Oxidative stress induced necroptosis activation is involved in the pathogenesis of hyperoxic acute lung injury.
Analysis of different levels of positive end-expiratory pressure during lung retrieval for transplantation: an experimental study
Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine.
Apoptosis, Autophagy, and Necrosis in Murine Embryonic Gonadal Ridges and Neonatal Ovaries: An Animal Model
Biochemically, necroptosis is defined as a spectrum between uncontrolled random cell death and programmed cell death (13,14,15).
Evaluation of Behavior, Learning, Memory Along with Apoptosis, Neuronal Damage, and GABA-A Alpha-1 Receptor Level After Status Epilepticus in Immature and Mature Rats/Immatur ve Matur Sicanlarda Status Epileptikus Sonrasi Apoptoz, Noronal Hasar, GABA-A Alfa-1 Reseptor Miktari ile Davranis, Ogrenme ve Hafizanin Degerlendirilmesi
Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target.
The Antiproliferative Activity of Colchicum umbrosum Plant Extract and Paclitaxel on C-41 and Vero Cells
Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining.
Comparison of Cisplatin with Lipoplatin in Terms of Ototoxicity
Moreover, autophagy activation is observed in a number of necrotic-like programmed cell death types, including necroptosis and autosis; however, the contribution of autophagy to these novel death pathways has not been thoroughly analyzed (41).
Autophagy and liver cancer
Among them, the activation of self-reactive lymphocytes and their infiltration in the pancreas, followed by the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNF-[alpha]), which united with its membrane receptor on the PBC, activate intracellular signaling pathways that end in the induction of proapoptotic mechanisms and, in some cases, cell death through necroptosis [13, 14].
Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
Necroptosis results from oligomerization of mixed lineage kinase domain-like protein (MLKL) [7], which is initiated by receptor-interacting serine/threonine-protein kinase 3- (RIPK3-) dependent phosphorylation [8, 9].
Elevated Serum Levels of Mixed Lineage Kinase Domain-Like Protein Predict Survival of Patients during Intensive Care Unit Treatment
Wang, "Retinal pigment epithelial cell necroptosis in response to sodium iodate," Cell Death Discovery, vol.
HMBG1 as a Driver of Inflammatory and Immune Processes in the Pathogenesis of Ocular Diseases
The HSV R1 protein is involved in evasion of cell death by preventing necroptosis in human but not mouse cells [129-131].
Questioning the Extreme Neurovirulence of Monkey B Virus (Macacine alphaherpesvirus 1)
MTT Assay in the Presence of Caspase Inhibitor (Z-VAD-FMK) and Necroptosis Inhibitor (Necrostatin-1) and Oxidative Stress Induce Necrosis Inhibitor (IM-54).
Luminescent Iridium Complex-Peptide Hybrids (IPHs) for Therapeutics of Cancer: Design and Synthesis of IPHs for Detection of Cancer Cells and Induction of Their Necrosis-Type Cell Death

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