necroptosis

A more recent term for regulated cell necrosis, which is carried out by so-called death receptors—e.g., tumour necrosis factor receptor 1, which requires receptor-interacting protein kinase 1 (encoded by RIPK1) and receptor-interacting protein kinase 3 (encoded by RIPK3). Necroptosis requires the active disintegration of mitochondrial, lysosomal and plasma membranes, and it is pathogenetically linked to ischaemic injury, neurodegeneration and viral infection, making the process an attractive therapeutic target in the future. It contrasts to apoptosis (formerly regarded as the only form of programmed cell death to be carried out during development, homeostasis and disease) and to necrosis (which is regarded as an unregulated and uncontrollable process).

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Selective cytotoxicity of vanadium complexes on human pancreatic ductal adenocarcinoma cell line by inducing necroptosis, apoptosis and mitotic catastrophe process.

Two novel Mg(II)-based and Zn(II)-based complexes: inhibiting growth of human liver cancer cells

ROS increase leading to necroptosis and ferroptosis in melanoma cells.

Vitrification of Mouse MII Oocyte Decreases the Mitochondrial DNA Copy Number, TFAM Gene Expression and Mitochondrial Enzyme Activity

regulated cell death, especially apoptosis and necroptosis, are natural barriers that restrict malignant cells from surviving and disseminating.

The Interplay Of Cell Death Pathways In Cancer Cell Survival And Resistance To Therapy (r01)

Grand challenges in cell death and survival: apoptosis vs necroptosis.

Monitoring in vitro response of selenium-treated human prostate cells by [sup.1]H NMR spectroscopy

It is anticipated that this process is responsible for the CSF aggregates linked to motor neuron destruction, and that this process may stimulate execution of necroptosis in astrocytes, which is selectively destructive to motor neurons.

Hypothesis: osseous spinal injury & reinjury as a risk factor, biomarker and etiological factor in sporadic ALS

Calpain: A molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure.

Inhibition on Apoptosis Induced by Elevated Hydrostatic Pressure in Retinal Ganglion Cell-5 via Laminin Upregulating [beta]1-integrin/Focal Adhesion Kinase/Protein Kinase B Signaling Pathway

So their bystander effect on long-term viable myocardial adjacent cells in perinecrotic region could cause probably a kind of successive numerous cell's suicide so that Cx43 would contribute numerous jeopardised cardiomyocytes to undergo apoptosis and/or necroptosis during reperfusion.

Apoptosis kinetics at reperfusion period in patients with acute ST-Segment Elevation Myocardial Infarction undergoing primary percutaneous coronary intervention and treated with thrombolytic therapy

Inhibitors of apoptosis, oxidative stress and necroptosis were tested to evaluate their protective effect against stenodactylin cytotoxicity.

Apoptosis and necroptosis induced by stenodactylin in neuroblastoma cells can be completely prevented through caspase inhibition plus catalase or necrostatin-1

Necroptosis was recently discovered as one form of programmed cell death (PCD) that shares characteristics with both necrosis and apoptosis.

Intracerebral Hemorrhage, Oxidative Stress, and Antioxidant Therapy

Apoptosis and necroptosis are induced in rainbow trout cell lines exposed to cadmium.

Environmental quality of an estuary in Amazon delta using immunohistochemical and morphological analyses of gill as biomarkers/Qualidade ambiental de um estuario no delta amazonico utilizando analises imunohistoquimicas e morfologicas de branquias como biomarcadores

The exact mechanism of cell death is not known but proposed mechanism after mechanical trauma is due to necroptosis, apoptosis, autoptosis or due to pyroptosis.

TRAUMATIC BRAIN INJURY: A COMMON NEUROSURGICAL ENTITY

Among specific topics are detecting apoptosis in cell-free systems, analyze cellular necroptosis, the transglutamination of proteins involved in apoptosis, fluorometric methods for detecting mitochondrial membrane permeabilization during apoptosis, the genetic mapping of anti-apoptosis pathways in myoloid progenitor cells, and a reliable method for detecting programmed cell death in yeast.