necrolytic migratory erythema

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Related to necrolytic migratory erythema: glucagonoma, vipoma, somatostatinoma, erythema gyratum repens

nec·ro·lyt·ic mi·gra·to·ry er·y·the·ma

an erythematous, scaling, and sometimes bullous erosive dermatitis occurring irregularly in plaques chiefly on the lower trunk, buttocks, perineum, and thighs; associated with weight loss, anemia, stomatitis, and elevation of plasma glucagon in islet cell tumor (glucagonoma) of the pancreas.
See also: glucagonoma syndrome.

necrolytic migratory erythema

A dermopathy associated with glucagonoma syndrome, which is characterised by waxing and waning erythematous patches that blister centrally, erode, then crust over and heal with hyperpigmentation in 10-day cycles. The lesions are often annular. They become confluent in severely affected areas. While no site is immune, NME is most common on the perineum, buttocks, groin, lower abdomen, and lower extremities, and other areas of pressure and friction.

Clinical findings
Pain, pruritus, atrophic glossitis, cheilosis, splitting of nails, buccal mucositis, dyspareunia; serum levels of glucagon do not correlate well with clinical disease.

necrolytic migratory erythema

Dermatology A plaque dermatopathy seen on the lower trunk, buttocks, perineum, and thighs of Pts with a glucagonoma of the pancreas Clinical Erythematous, scaling, ± bullous, erosive lesions accompanied by weight loss, anemia, stomatitis Lab ↑ Glucagon. See Glucagonoma.


redness of the skin caused by congestion of the capillaries in the lower layers of the skin. It occurs with any skin injury, infection or inflammation.

erythema ab igne
that due to exposure to radiant heat.
erythema chronicum migrans
the early skin rash at the site of the tick bite which infects humans with Borellia burgdorferi (Lyme disease); rarely seen in dogs.
erythema multiforme
a disease of unknown etiology, but is sometimes drug-related; presumed to be immune-mediated. It occurs in all species and is characterized by an acute onset of erythematous macules, papules, vesicles or bullae. There may also be fever, depression and anorexia.
erythema multiforme major
a rapidly fulminating, ulcerative form of erythema multiforme with involvement of oral mucosa and systemic signs.
necrolytic migratory erythema
in humans, a skin disease associated with glucagon-secreting tumors of the pancreas. The same association has not been observed in dogs, but disease of the liver and pancreas is often present. There are vesicles and crusted, ulcerated lesions, mainly on the face, mucocutaneous areas, distal limbs and feet.
erythema nodosum
a rare disorder in dogs characterized by fever, depression, arthralgia and septal panniculitis.
toxic erythema, erythema toxicum
a generalized erythematous or erythematomacular eruption due to administration of a drug or to bacterial toxins or other toxic substances.
References in periodicals archive ?
Failure to document hyperglucagonemia in a dog with diabetic dermatopathy resembling necrolytic migratory erythema.
The symptoms are a necrolytic migratory erythema, often perioral or intertriginous.