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Pertaining to or characterized by necrobiosis.


Pertaining to or characterized by necrobiosis.


(nek-ro-bi-o'sis) [? + biosis, life]
Gradual degeneration and swelling of collagen bundles in the dermis. See: necrosisnecrobiotic (ne?kro-bi-ot'ik), adjective

necrobiosis lipoidica diabeticorum

A skin disease marked by necrotic atrophy of connective and elastic tissue. The lesions have a central yellowish area surrounded by a brownish border and telangiectases and usually present on the anterior surface of the legs. The disease is commonly found in people who have had diabetes mellitus for many years. Beginning as 1 to 3 mm papules or nodules, the lesions enlarge to become waxy or shiny round plaques that are reddish brown at first and later become yellow atrophic lesions. Synonym: diabetic dermopathy

Patient care

Infection and, occasionally, ulceration result when an affected area is traumatized. A variety of treatments have been tried for patients who find the rash unsightly; none are definitively effective. The patient also should be taught methods for protecting legs and other affected areas from injury. Graduated compression stockings should be worn, and the legs should be rested frequently.

References in periodicals archive ?
These are necrobiotic palisading granulomas, interstitial form and granuloma of sarcoidal or tuberculoid type.
After a 25-year course of necrobiotic xanthogranuloma with paraproteinemia, this patient died of bacteremia following pancytopenia as he developed myeloma, Dr.
In particular, isolated rheumatoid nodules or necrobiotic granulomas (deep granuloma annulare) have a decided potential for this mimicry, vis-a-vis the alternative diagnosis of epithelioid sarcoma.
Histologically, epithelioid sarcoma and isolated necrobiotic granulomas may also be similar.
Adult orbital xanthogranulomatous disease presents with variable clinical features from which 4 subtypes are subclassified: adult-onset xanthogranuloma (AOX), necrobiotic xanthogranuloma (NBX), Erdheim-Chester disease (ECD), and adultonset asthma and periocular xanthogranuloma (AAPOX).
Necrobiotic xanthogranuloma is characterized by the presence of subcutaneous skin lesions that tend to ulcerate and become fibrotic.
When AOXGD presents with monoclonal gammopathy, as in cases of necrobiotic xanthogranuloma or in rare occasions, AAPOX, it needs to be differentiated from multiple myeloma with involvement of the orbit or plasmacytoma of the eye and/or of the orbit.
Small nerve units were also caught up in this scarifying process, which failed to show necrobiotic foci, fibrinoid material, or nuclear dust.
Ulceration and necrosis are typical, with the frequent central necrosis (Figure 2), resulting in a pseudogranulomatous appearance, which can mimic benign necrobiotic granulomatous lesions.
69) Colloidal iron or Alcian blue stains may reveal mucin in the central necrobiotic foci of granuloma annulare, (70) but in our experience that finding is not typical of ES.
Epithelioid sarcoma and isolated necrobiotic granuloma: a comparative immunocytochemical study.