nebulin


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neb·ul·in

(neb'yū-lin), [MIM*161650]
A large protein, constituting about 3% of skeletal muscle protein; may aid in the organization of actin filaments as well as in actin polymerization.
[L. nebula, mist, fog, fr. G. nephelē, + -in]

nebulin

(neb′yŭ-lin)
A large protein (600 to 800 kD in mass) found in the thin filaments of contractile muscles, where it binds to actin.
References in periodicals archive ?
Nebulin. Nebulin is a giant protein (600-900 kDa) that is also part of the thin filaments.
In the peripheral region of the Z-line, nebulin interacts with desmin, suggesting that the nebulin could be involved in maintaining the lateral alignment of myofibrils, an essential property for a coordinated and efficient contractile activity (Donner et al.; Pappas et al.).
Complete genomic structure of the human nebulin gene and identification of alternatively spliced transcripts.
Nebulin, a major player in muscle health and disease.
Nebulin regulates the assembly and lengths of the thin filaments in striated muscle.
New insights into the structural roles of nebulin in skeletal muscle.
Detection of giant myofibrillar proteins connectin and nebulin in fish meat by electrophoresis in 3-5 gradient sodium dodecyl sulfate polyacrylamide slab gels.
Architecture of the sarcomere matrix of skeletal muscle: immunoelectron microscopic evidence that suggests a set of parallel inextensible nebulin filaments anchored at the Z line.