Changes in fatal and near fatal asthma
in an urban area of South Africa from 1980-1997.
As evidence of this, low socio-economic class was closely correlated with fatal or near fatal asthma
in a South African study; asthma mortality was highest over weekends, when access to care was poorest.
(27) The results of another study indicate that extensive small airway abnormalities may be associated with near fatal asthma
, and that these abnormalities are partially reversible after the successful control of asthma symptoms.
long-acting [beta.sub.2] agonist, theophylline or leukotriene antagonists, together with inhaled corticosteroids * Daily asthma symptoms requiring rescue medication * Persistent airway obstruction ([FEV.sub.1] <80% predicted; diurnal PEF variability >20%) * One or more urgent care visits for asthma in the last year * Three or more oral steroid bursts in the last year * Prompt deterioration with <25% reduction in oral or inhaled corticosteroid dose * Near fatal asthma
event in the past At least one or both major criteria and two minor criteria.
Such difficult to control patients also include some special phenotypes such as 'brittle asthma' and 'near fatal asthma
', besides the patients with persistent risk thctors, poor responders or steroid resistant patients (and others).