The firm is planning to start a natural history of disease
trial to gather further information about the progression of Alport syndrome and to inform future clinical development plans of RG-012, a key programme under its 'Clinical Map Initiative'.
The disadvantages of Cross-sectional surveys are; inability to estimate the natural history of disease
, incidence or risk factor identification due to lack of temporality, which need longitudinal studies.
Early institution of immunotherapy has been suggested to improve the outcome and alter the natural history of disease
. (3) Here, we report of a young girl diagnosed with RE based on clinical features, electroencephalography (EEG) and imaging findings.
"This data suggests that crizotinib may prolong overall survival for these patients who have ALK in their lung tumors and may improve the natural history of disease
"We propose that routine or targeted screening with chest CT at the time of aortic aneurysm diagnosis may be indicated, not only to really define the natural history of disease
, but more importantly to try to prevent late aortic events," Dr.
New and updated information includes new disease outbreaks, the history of epidemiology and the natural history of disease
, morbidity and mortality data, health disparities, data sources, and professional issues in epidemiology.
Ussery, of Pfizer Global Research and Development in New London, Conn., also noted that disease manifestation is different in children than in adults, including "the natural history of disease
, the severity of disease.
The ideal marker test would be able to accurately stage disease and also be sensitive to changes in fibrosis induced by therapy or the natural history of disease
* The natural history of disease
is largely unpredictable in a given patient.
For example, community health nursing teaches the concepts of natural history of disease
, which include health promotion and prevention, early diagnosis and treatment, and rehabilitation.
We use these data to estimate the magnitude of a health problem in a population and to portray the natural history of disease
(i.e., the waxing and waning of incidence).