NPPC

(redirected from natriuretic peptide C)

NPPC

A gene on chromosome 2q24-qter that encodes a member of the natriuretic peptide family. The secreted NPPB protein product binds to NPR2 and NPR3 receptors; it is involved in natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and plays a key role in cardiovascular homeostasis. NPPC also plays a role in endochondral ossification by regulating cartilaginous growth plate chondrocyte proliferation and differentiation.
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The CNP products encoded by the NPPC [2] (natriuretic peptide C) gene have been difficult to measure accurately because their plasma concentrations are considerably lower than for the ANP and BNP peptides.