natriuretic peptide


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Related to natriuretic peptide: natriuretic peptide B

a·tri·al na·tri·u·ret·ic pep·tide (ANP),

a 28-amino acid peptide (α-ANP) derived from cardiac atria, several smaller fragments of α-ANP, and a dimer of α-ANP with 56 amino acids (β-ANP) that are present in plasma in heart failure. Among other actions, ANP promotes renal salt and water excretion, increases capillary function, and decreases arterial pressure and the secretion of renin, angiotensin, aldosterone, and antidiuretic hormone.

natriuretic peptide

Any peptide that stimulates the kidneys to excrete salt and water.
See also: peptide

natriuretic peptide

A PEPTIDE present in the blood and raised in quantity in people with long-term (chronic) HEART FAILURE. It arises in the upper chambers of the heart, probably as a result of stretching, and causes blood vessels to widen and the output of urine to increase. By increasing output of urinary sodium and, with it, water, it helps to relieve the OEDEMA that is a feature of HEART FAILURE. Also known as atrial natriuretic factor. B-type natriuretic peptide is released by ventricular muscle cells and is used as a therapeutic agent in heart failure. It is also used as a biomarker for differential diagnosis of breathlessness and for preclinical assessment of heart failure.
References in periodicals archive ?
Biodesign of a renal-protective peptide based on alternative splicing of B-type natriuretic peptide.
It has been demonstrated that BNP (like ANP) binds to the natriuretic peptide receptor type A (NPR-A) resulting in increased intracellular cyclic GMP production (14).
Multimarker approach to risk stratification in non-ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide.
In this setting, despite the value of natriuretic peptide assays, inappropriate interpretation and/or unrestrained use of these tests for inappropriate patients would result in results difficult to interpret and associated with a cost outlay that would make the proposition of using the natriuretic peptide assays untenable.
Serum levels of natriuretic peptides may be elevated in patients with acute MI, candidates for renal dialysis, or people who have undergone renal dialysis.
One of the issues in the field, however, is that different physician groups may have different degrees of expertise, and so natriuretic peptide measurement may be more helpful for those without vast experience in heart failure and be less important for those who are more familiar with this patient group.
Both genes are involved in the production of atrial and B-type natriuretic peptides (ANP and BNP).
Key Words: brain natriuretic peptide, N-terminal probrain natriuretic peptide, cardiac surgery, intensive care
Tests used to measure plasma levels of B-type natriuretic peptide (BNP) are becoming the preferred method of identifying CHF in dyspneic patients.
The treatments that should be initiated vary dramatically for these different conditions; thus, diagnostic tools, such as the natriuretic peptide assays, that can help distinguish between these conditions are very important.
A recombinant form of human B-type natriuretic peptide (hBNP) for people with acutely decompensated congestive heart failure (CHF), with shortness of breath at rest or with minimal activity.