natriuretic peptide


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to natriuretic peptide: natriuretic peptide B

a·tri·al na·tri·u·ret·ic pep·tide (ANP),

a 28-amino acid peptide (α-ANP) derived from cardiac atria, several smaller fragments of α-ANP, and a dimer of α-ANP with 56 amino acids (β-ANP) that are present in plasma in heart failure. Among other actions, ANP promotes renal salt and water excretion, increases capillary function, and decreases arterial pressure and the secretion of renin, angiotensin, aldosterone, and antidiuretic hormone.
Farlex Partner Medical Dictionary © Farlex 2012

natriuretic peptide

Any peptide that stimulates the kidneys to excrete salt and water.
See also: peptide
Medical Dictionary, © 2009 Farlex and Partners

natriuretic peptide

A PEPTIDE present in the blood and raised in quantity in people with long-term (chronic) HEART FAILURE. It arises in the upper chambers of the heart, probably as a result of stretching, and causes blood vessels to widen and the output of urine to increase. By increasing output of urinary sodium and, with it, water, it helps to relieve the OEDEMA that is a feature of HEART FAILURE. Also known as atrial natriuretic factor. B-type natriuretic peptide is released by ventricular muscle cells and is used as a therapeutic agent in heart failure. It is also used as a biomarker for differential diagnosis of breathlessness and for preclinical assessment of heart failure.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
N-terminal pro-brain natriuretic peptide and abnormal brain aging: The AGES-Reykjavik Study.
Mitral annular motion as a surrogate for left ventricular function correlation with brain natriuretic peptide levels.
The identification of CNP was based on its structural similarity to atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) (20).
Negative linear relationships between BMI and plasma natriuretic peptide levels have been reported [31, 32].
Other hypothesis is that factors such as age, gender, and systolic function are more important than diabetes in determining the natriuretic peptide levels, and once such parameter's influence is abolished, no influence is left over for diabetes in BNP levels.
It has been shown that changes in natriuretic peptide levels over time in response to therapy are powerful indicators of prognosis, that is, patients in whom natriuretic peptide levels decrease in response to ongoing medical management seem to have a better prognosis than those with increased or similar levels compared to that of initial presentation.
Can brain natriuretic peptide predict the outcome in patients with acute pulmonary embolism?
Natriuretic peptide levels were similar in patients with normal diastolic function (n=16; NT-proBNP: median, 168 pmol/L; interquartile range, 118 to 289 pmol/L), an impaired relaxation pattern (n=24; NT-proBNP: median, 269 pmol/L; interquartile range, 164 to 778 pmol/L) or a pseudonormal pattern (n=5; NT-proBNP: median, 846 pmol/L; interquartile range, 398 to 2867 pmol/L).
Angiotensin II (Ang II) that displays hypertensive and prooxidant properties, by one side, and the atrial natriuretic peptide (ANP) and renal dopamine, by the other side, both with hypotensive and antioxidant properties, are local factors closely related to the development and progression of glomerular and tubular injury [7, 8].
With expiry not until March 2027, both the patents support the company's programme developing synthetic mimetics of the neuropeptide hormone atrial natriuretic peptide.