nasopharyngeal cancer

nasopharyngeal carcinoma

A rare (in the West) malignancy which is endemic in regions of southern China—where it comprises up to 18% of cancers—as well as in southeast Asia. It is linked to EBV infection, diets high in nitrosamines and inhaled carcinogens. It is more common in males and has a peak incidence of age 40 to 50.

DiffDx
Lymphoma (DLCBL, Hodgkin's), reactive lymphoid proliferation, sarcomas.

Management
Radiotherapy, chemotherapy.

Prognosis
Stage dependant; 5-year survival is 55%.

Nasopharyngeal carcinomas (WHO, 2005)
- Keratinising squamous cell carcinoma
- Non keratinsing carcinoma
  • Differentiated
  • Undifferentiated
- Basaloid squamous cell carcinoma
- Nasopharyngeal cancer, staging
  • Stage I—Lesion confined to nasopharynx.
  • Stage II
    A) Lesion extends to oropharynx and/or nasal fossa.
    B) Lesion extends to nearby lymph nodes or to parapharyngeal region.
  • Stage III—Lesion spread to lymph nodes on both sides of the neck or nearby bones or sinuses.
  • Stage IV
    A) Spread beyond nasopharynx to other areas in head; possible spread to regional lymph nodes.
    B) Spread beyond nasopharynx to other areas in head and to lymph nodes above clavicle, or are ≥ 6 cm in greatest dimension.
    C) Metastasised.

nasopharyngeal carcinoma

Nasopharyngeal cancer A rare malignancy, which is endemic to regions of southern China and Southeast Asia; persons with serologic markers for EBV–IgA antibodies against EBV capsid antigen and/or neutralizing antibodies against EBV-specific DNase have a 3-fold cumulative risk of nasopharyngeal cancer if one marker was positive and a 35-fold risk if both markers are positive. See Epstein-Barr virus.
Nasopharyngeal cancer
Stage I Lesion confined to nasopharynx
Stage II
A  Lesion extends to oropharynx and/or nasal fossa
B  Lesion extends to nearby lymph nodes or to parapharyngeal region
Stage III Lesion spread to lymph nodes on both sides of the neck or to nearby bones or sinuses
Stage IV
A Spread beyond nasopharynx to other areas in head, and  possibly to nearby lymph nodes
B Spread beyond nasopharynx to other areas in head and to lymph nodes above clavicle or are ≥ 6 cm
C Lesion has metastasized
References in periodicals archive ?
It is being treated on nasopharyngeal cancer patients with positive Epstein-Barr virus infection.
BeiGene announced preliminary results of tislelizumab, its investigational anti-PD-1 inhibitor, in Chinese patients with nasopharyngeal cancer that were presented in a poster at the 2019 American Society of Clinical Oncology Annual Meeting.
Actor Kim Woo-bin, who was diagnosed with nasopharyngeal cancer in May 2017, appeared to be healthy when he was spotted at the Gimpo International Airport on Saturday after his return from Japan.
After months of trips to the doctor, 22-year-old Amie, who lives in Castle Douglas, was diagnosed with stage four nasopharyngeal cancer on November 2.
In retrospective, we searched for the incidence of 21 types of cancer in both genders in the following order: leukemia; multiple myeloma; lymphoma; thyroid cancer; brain and nervous system cancers; bladder cancer; kidney cancer; prostate cancer; ovarian cancer; uterine cancer; cervical cancer; breast cancer; tracheal, bronchus and lung cancer; pancreatic cancer; gallbladder and biliary tract cancers; liver cancer; colon and rectum cancers; stomach cancer; esophageal cancer; nasopharyngeal cancer; and lip and oral cavity cancers in the period between 1990 to 2016.
The company is currently conducting a multi-center Phase III trial targeting nasopharyngeal cancer, and a Phase I trial targeting cervical cancer and oropharyngeal cancer, set to move into Phase II in 2019.
The 19-year-old battled with nasopharyngeal cancer, a rare form of head and neck cancer, for three years.
Tumors that can be positive for EBV include nasopharyngeal cancer and Hodgkin lymphoma.
South Korean actor Kim Woo-bin was spotted in public after a long hiatus to recover from nasopharyngeal cancer.
Ishak died at 65 after a long battle with nasopharyngeal cancer.
John 'Ray' Smith was diagnosed with nasopharyngeal cancer which affects the part of the throat connecting the back of the nose to the back of the mouth.
Cancers of the head and neck include tumors in areas above the collarbone, with the three major subdivisions including oral cancer, laryngeal cancer, and nasopharyngeal cancer. This type of cancer typically starts in the mouth, nose, throat, larynx, sinuses, or salivary glands.