Naringenin-oxime (NOX) is a new derivative compound of naringenin
(4,5,7-trihydroxyflavanone) which is a predominant flavanone in citrus fruits including oranges and grapefruit .
Chlorogenic acid, caffeic acid, p-coumaric acid, ferulic acid, quercetin, quercetin rutinoside (rutin), naringenin
, naringin, 2,2-diphenyl-1-picrylhydrazyl (DPPH), gallic acid, Folin-Ciocalteu's phenol reagent, and formic acid were purchased from Sigma-Aldrich (Steinheim, Germany).
In vitro studies in human hepatoma cell line (HepG2) have shown that naringenin
and hesperetin reduce the availability of lipids for the assembly of apolipoprotein (apo) B-containing lipoproteins, an effect mediated by the reduction of ACAT activity (Wilcox et al.
8-Prenylnaringenin (8-PN) was synthesized from naringenin
as described previously (Gester et al.
Professor Cathie Martin, lead author of the paper published in Science Advances, explains: "Many flavones are synthesised using a compound called naringenin
as a building block.
As well as being a good source of dietary fiber (8% Daily Value) and potassium (5% DV), half a medium grapefruit provides 64% DV of vitamin C and 28% DV of vitamin A, and also contains the health protective plant chemicals naringenin
, limonin, lycopene (in pink and red varieties), and beta-carotene.
It is found that naringenin
, an antioxidant derived from bitter-flavoured grapefruit and other citrus fruits, may cause the liver to break down fat while increasing insulin sensitivity, mimicking the actions of lipid-lowering and anti-diabetic drugs.
caudatus contained a number of phenolic compounds including quercetin, proanthocynidin, chlorogenic acid, catechin, epicatechin, myricetin and naringenin
which have contributed to its high antioxidant activity .
Influence of naringenin
on the activity of enzymes participating in steroidogenesis in male rats.
Flavonoid biosynthesis is initiated by an enzymatic step catalyzed by chalcone synthase (CHS) that results in production of yellow color chalcone (naringenin
It is a new single molecule 'derived from naringenin
, a flavanone naturally occurring in the peel of citrus fruit.
Parmar, "The gastric anti-ulcer activity of naringenin
, a specific histidine decarboxylase inhibitor," International Journal of Tissue Reactions, vol.