nanophthalmos


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Related to nanophthalmos: Microphthalmos

nanophthalmos

 [nan″of-thal´mus]
abnormal smallness in all dimensions of one or both eyes in the absence of other ocular defects; see microphthalmos.

mi·croph·thal·mos

(mī'krof-thal'mos),
Abnormal smallness of the eye.
[micro + G. ophthalmos, eye]

microphthalmia

A congenital reduction in eye size, with the ocular bulb measuring 1/2 of the normal volume in extreme cases, due to an abnormal development of the optic vesicle in the optic cup.

Aetiology
• Congenital—e.g., encephalo-ophthalmic dysplasia, focal dermal hypoplasia, Hallermann-Streiff syndrome, incontinentia pigmenti, Lenz microphthalmia syndrome, retinopathy of prematurity, trisomy 13-15.
• Infectious—e.g., CMV, herpes, rubella, toxoplasmosis.
• Toxins—e.g., foetal alcohol syndrome.

Incidence
14/105; 3–11% of all cases of blindness.

microphthalmia

Congenital anomaly in which the eyeball is abnormally small and often deeply set in a small orbit. It is typically hyperopic. Syn. microphthalmos; microphthalmus. When there is no other abnormality (e.g. coloboma of the iris, microphthalmos with cyst), the condition is called nanophthalmos (Fig. M10). See anophthalmia; monophthalmia; pseudoptosis.
Fig. M10 Right eye microphthalmos (From Kanski 2007, with permission of Butterworth-Heinemann)enlarge picture
Fig. M10 Right eye microphthalmos (From Kanski 2007, with permission of Butterworth-Heinemann)
References in periodicals archive ?
Gouras, "Retinal degeneration with nanophthalmos, cystic macular degeneration, and angle closure glaucoma.
Ghazi, "Nanophthalmos and hemiretinal vein occlusion: a case report," Saudi Journal of Ophthalmology, vol.
Demirok, "Subfoveal choroidal thickness measurements with enhanced depth imaging optical coherence tomography in patients with nanophthalmos," British Journal of Ophthalmology, vol.
Cam, "Optical coherence tomography of bilateral nanophthalmos with macular folds and high hyperopia," Case Reports in Ophthalmological Medicine, vol.
Esfandiari, "Nanophthalmos," Journal of Ophthalmic and Vision Research, vol.
Martorina, "Familial nanophthalmos," Journal Francais D'Ophtalmologie, vol.
Kumar, "Bilateral nanophthalmos, pigmentary retinal dystrophy, and angle closure glaucoma--a new syndrome?," British Journal of Ophthalmology, vol.
Monteiro-Grillo, "Bilateral nanophthalmos and pigmentary retinal dystrophy-an unusual syndrome," Graefe's Archive for Clinical and Experimental Ophthalmology, vol.
Zenteno et al., "Mutations in a novel serine protease PRSS56 in families with nanophthalmos," Molecular Vision, vol.
Siemiatkowska et al., "A novel crumbs homolog 1 mutation in a family with retinitis pigmentosa, nanophthalmos, and optic disc drusen," Molecular Vision, vol.
Villanueva-Mendoza, "Homozygosity mapping identifies the Crumbs homologue 1 (Crb1) gene as responsible for a recessive syndrome of retinitis pigmentosa and nanophthalmos," American Journal of Medical Genetics Part A, vol.
Hart-Holden et al., "Mutations of VMD2 splicing regulators cause nanophthalmos and autosomal dominant vitreoretinochoroidopathy (ADVIRC)," Investigative Ophthalmology and Visual Science, vol.