naltrexone hydrochloride


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naltrexone hydrochloride

[naltrek′sōn]
an oral opioid antagonist.
indications It is prescribed to block the effects of opioid analgesics, including heroin, morphine, and methadone, in patients recovering from addiction and to treat ethanol dependence.
contraindications Acute hepatitis or liver failure prohibits its use. Periodic liver function tests are recommended for all patients. Patients must be completely free of opioids before taking naltrexone to prevent severe withdrawal symptoms. Patients must be educated that their tolerance to morphine disappears while they are on naltrexone and that they can be much more sensitive to opioids after discontinuing naltrexone; past dosages of heroin, morphine, etc., could now be fatal.
adverse effects The most serious adverse effects are abdominal pain, cramps, nausea, vomiting, headache, sleep disorders, and joint and muscle pain. Some adverse effects may actually be withdrawal symptoms rather than reactions to naltrexone.
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In our results, the use of naltrexone hydrochloride did not produce the expected effect, probably due to unbalance in FSH production, number of receptors in Sertoli cells or both.
It was demonstrated in single dose studies for ELI-216 that no quantifiable blood levels of naltrexone hydrochloride were released at a limit of quantification ("LOQ") of 7.
The study also helped determine the appropriate levels of naltrexone hydrochloride required to reduce or eliminate the euphoria experienced by subjects who might take crushed product to achieve a "high".
The Company's Phase I trial showed that there were no quantifiable levels of naltrexone hydrochloride in the bloodstream when ELI-216 was administered intact to healthy subjects, but was released into the bloodstream as intended when ELI-216 was crushed.
ELI-216 uses a pharmacological agonist-antagonist combination approach of sustained release agonist oxycodone hydrochloride, intended for use by patients with moderate to severe chronic pain, and an antagonist, naltrexone hydrochloride, formulated to deter abusers of the drug.
OxyNal(TM) uses a pharmacological agonist-antagonist combination approach of sustained release agonist oxycodone hydrochloride, intended for use in patients with moderate to severe chronic pain, and an antagonist, naltrexone hydrochloride, formulated to deter abusers of the drug.
The product tested, OxyNal(TM), uses a pharmacological agonist-antagonist combination approach of sustained release agonist oxycodone hydrochloride, intended for use in patients with moderate to severe chronic pain, and an antagonist naltrexone hydrochloride formulated to deter abusers of the drug.