nalorphine


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Related to nalorphine: naloxone

nalorphine

 [nal´or-fēn]
a semisynthetic congener of morphine, used as an antagonist to morphine and related narcotics and in the diagnosis of narcotic addiction.

nal·or·phine

(nal-ōr'fēn),
An early antagonist of most depressant and stimulatory effects of morphine and related narcotic analgesics; precipitates severe withdrawal symptoms in morphine addicts, and counteracts the respiratory depression produced by morphine and related compounds; when administered in the absence of narcotics, nalorphine has mildly analgesic and respiratory depressant effects in nonaddicts; superseded by naloxone hydrochoride.
Synonym(s): N-allylnormorphine

nalorphine

A morphine derivative which reversses the activity of morphine and other narcotics. See Opioids.

nalorphine

A narcotic antagonist drug so similar in structure to MORPHINE that it occupies morphine receptor sites on cell membranes and prevents morphine from acting. A small dose of the drug, given to a morphine addict, can induce withdrawal symptoms within a matter of minutes.
References in periodicals archive ?
Drugs and nalorphine were obtained from Cambridge Isotope Laboratories and Sigma.
Nalorphine (300 [micro]L of a 25 mg/L solution) was added to 1 mL of urine for procedure A (morphine, 6-AM, and codeine), and nalorphine (200 F.i,L of a 2.5 mg/L solution) was added to 2 mL of urine for procedure B (heroin and AC).
Compound Retention time, min Acetaminophen a Amitriptyline No derivative Amphetamine b Bufotenine 9.87 Buprenorphine 20.75 Caffeine No derivative Cocaine No derivative Codeine 13.59 Desipramine 13.69, 14.33, 15.37 Diazepam 14.41 Diphenylhydantoin a Doxepin No derivative Ephedrine 4.70 Fentanyl No derivative Fluoxetine 5.90, 10.85 Haloperidol No derivative Heroin No derivative Imipramine 13.53, 13.87 MDA 6.46, 7.88 MDMA 7.62, 9.00 Meperidine No derivative Methadone No derivative Methamphetamine b Morphine 13.51 Nalorphine 14.57 N-n-propylnorbuprenorphine 19.52 Norbuprenorphine 18.81 Nortriptyline 14.07 Oxazepam No derivative Pentazocine 11.56 Phenobarbital a Propanolol 11.74, 13.09 Propoxyphene No derivative Tetrahydrocannabinol a (a) Drug is eliminated during back-extraction into acid.