nalmefene


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nalmefene

 [nal´mĕ-fēn″]
an opioid antagonist, used as the hydrochloride salt in the treatment of opioid overdose and postoperative opioid depression.

nalmefene

(năl′mə-fēn′)
n.
A drug, C21H25NO3, used as an antagonist to narcotic drugs.
References in periodicals archive ?
Nalmefene, also called Selincro, is suitable for anyone who regularly drinks high amounts of alcohol, which is defined by the World Health Organisation as 7.5 units a day for men and five units a day for women.
Nalmefene has also been approved for use in Norway, Finland, Poland and the Baltic countries last month.
Scott said that to make sure a patient is opiate-free before starting naltrexone or nalmefene, and he warned again that compliance is a major obstacle.
EVIDENCE SUMMARY Naltrexone (50 mg qd), nalmefene (10-80 mg qd), and acamprosate (dose based on patient weight) are all superior to placebo and other agents such as the SSRIs, disulfiram, and serotonergic agents in reducing relapse rates and the phenomena of craving and in increasing abstinence rates.
Nalmefene (Cervene[R]), which is chemically and pharmacologically related to the narcotic antagonist naloxone, is a new type of opiate antagonist which more effectively binds to central opiate receptors and has no dose-dependent association with liver toxicity.[35] Based on results of earlier studies demonstrating histopathologic, metabolic and functional recovery consistent with neuroprotection, nalmefene is currently being assessed in phase III trials for neuroprotection in spinal and cerebral trauma and cerebral ischemia.[15,20] In recently completed clinical trials involving patients with acute ischemic stroke, treated within 6 hours of symptom onset, no safety concerns were evident with nalmefene therapy.
- The US Food and Drug Administration has granted Fast Track designation to nalmefene hydrochloride injection, US-based Purdue Pharma L.P.'s investigational opioid antagonist for the emergency treatment of known or suspected opioid overdose, the company said.
Wells Fargo analyst David Maris "completely" disagrees with the view that shares of Emergent BioSolutions (EBS) are weak today on news of Purdue Pharma's nalmefene injection receiving fast track designation from the FDA.
The company hopes to be given the green light by the Ministry of Health, Labour and Welfare to manufacture and distribute Nalmefene, a new drug to treat alcoholism.
Some European countries have approved nalmefene and sodium oxybate for AUD treatment.
Nalmefene is designed to help problem drinkers cut down on booze without them having to quit altogether.
Washington, Apr 12 ( ANI ): A potential new treatment for alcoholism called nalmefene has been found to be effective and safe for reducing alcohol consumption in alcohol dependent individuals.