nalidixic acid


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

nalidixic acid

 [nal″ĭ-dik´sik]
a quinolone antibacterial agent, active against most gram-negative bacteria causing urinary tract infection including Escherichia coli, Klebsiella and Enterobacter species, and some Proteus species. Pseudomonas species are generally resistant.

nal·i·dix·ic ac·id

(nal-i-dik'sik as'id),
An orally effective antibacterial agent used in the treatment of genitourinary tract infections.

nalidixic acid

/nal·i·dix·ic ac·id/ (nal-ĭ-dik´sik) a synthetic antibacterial agent used in the treatment of genitourinary infections caused by gram-negative organisms.

nalidixic acid

(nā′lĭ-dĭk′sĭk)
n.
An antibacterial drug, C12H12N2O3, used to treat urinary tract infections caused by gram-negative bacteria.

nalidixic acid

[nal′idik′sik]
an antibacterial.
indications It is prescribed in the treatment of certain urinary tract infections.
contraindications Renal or hepatic insufficiency, a history of convulsive disorders, or known hypersensitivity to this drug prohibits its use. It should not be used in children less than 3 months of age and should be used with care in prepubertal children.
adverse effects Quinolones have caused tendon rupture, especially in prepubertal children, and severe hypersensitivity reactions. Among the more serious effects are increased intracranial pressure, seizures, hemolytic anemia in people affected with glucose-6-phosphate dehydrogenase deficiency, and GI and neurological disturbances.

nalidixic acid

Antibiotics An early generation quinolone with a limited antimicrobial palate, primarily used for UTIs. See Quinolone.

nalidixic acid

A quinolone antibiotic drug, effective against GRAM NEGATIVE bacilli, including Proteus species, and much used for urinary infections. The drug is on the WHO official list. Brand names are Negram andUriben.

nal·i·dix·ic ac·id

(nali-diksik asid)
Orally effective antibacterial agent used to treat genitourinary tract infections.

nalidixic acid,

n an antibacterial prescribed in the treatment of urinary tract infections.

nalidixic acid

a naphthylidine derivative that inhibits DNA synthesis. Used for the treatment of urinary tract infections due to susceptible gram-negative bacteria. Side-effects in dogs include vomiting, diarrhea and seizures.
References in periodicals archive ?
In our study, the resistance to Nalidixic acid was observed in 71.
A marked increase in resistance to nalidixic acid and newer fluoroquinolones, combined with ESBL-mediated third-generation cephalosporin resistance, would leave limited treatment options for those with life-threatening bacterial infections.
Abbreviations used; Am, Amoxicillin; Amp, Ampicillin; Baci, Bacitracin; Chl, Chloramphenicol; Ery, Erythromycin; Kan, Kanamycin; Nal, Nalidixic acid, Neo, Neomycin; Oxy, Oxytetracyclin; P.
coli Resistance 1986-1989 2004-2005 (n = 129) (n = 77) Nitrofurantoin 12 (9%) 5 (6%) Nalidixic acid 19 (13%) 11 (14%) 1st generation Cephalosporin -- 10 (13%) 2nd generation Cephalosporin -- 5 (7%) 3rd generation Cephalosporin 4 (3%) 4 (5%) Norfloxacin -- 7 (9%) Ciprofloxacin -- 3 (4%) Amicacin 3 (2%) 0 (0%) Ampicillin 52 (40%) 42 (55%) Trimethoprim-Sulfamethoxazole 46 (36%) 39 (51%) Table 2.
MICs of isolates resistant to chloramphenicol, ampicillin and nalidixic acid were determined by agar dilution test using purified antibiotic powders (HiMedia Laboratories, Mumbai).
Because resistance to nalidixic acid is frequently associated with decreased susceptibility to fluoroquinolones, nalidixic acid resistance must be detected to monitor the emergence of highly resistant strains (14).
coli isolated from urine as well as to establish if resistance to nalidixic acid could constitute a good marker of resistance to the newest fluoroquinolones.
Overall, Shigella isolates had high rates of resistance to tetracycline (79%), trimethoprim-sulphamethoxazole (72%), ampicillin (56%), nalidixic acid (51%), and chloramphenicol (42%).
coli Klebsiella Pseudomonas Proteus (n=1204) pneumoniae aeruginosa mirabilis (n=802) (n= 406) (n=66) Ampicillin 14 12 0 41 Amoxicillin/ 16 11 0 44 clavulanic acid Cefazolin 29 20 0 57 Cefuroxime 29 28 0 57 Cefotaxime 44 49 15 65 Ceftriaxone 43 51 21 70 Ceftazidime 43 42 21 54 Cefepime 52 56 57 75 Piperacillin/ 73 57 61 97 Tazobactam Cefoperazone/ 86 62 70 88 Sulbactam Amikacin 86 86 83 99 Gentamicin 68 69 80 86 Nalidixic acid 15 24 0 17 Nitrofurantoin 47 15 0 0 Norfloxacin 33 32 0 33 Ciprofloxacin 44 56 47 79 Levofloxacin 52 60 61 55 Trimethoprim/ 36 37 20 57 Sulfamethoxazole Imipenem 92 72 69 100 Meropenem 69 69 70 100 Antibiotic Acinetobacter S.
Another research of Karachi is also the evident of high rate of resistance in Shigella against Ampicillin and nalidixic Acid 55.
75 [micro]g (SXT), nalidixic acid 30 [micro]g (NAL), norfloxacin 10 [micro]g (NOR), cefotaxime 30 [micro]g (TAX) and cefixime 5 [micro]g (FIX) was performed using Kirby-Bauer disk diffusion method and results were interpreted using breakpoints recommended by the Clinical Laboratory Standards Institute (CLSI) guidelines 2014 and 2015.
12 Antibiotics used for antibiogram determination of the collected strains among FQ were: norfloxacin, ciprofloxacin, ofloxacin, enoxacin, moxifloxacin, and sparfloxacin and nalidixic acid.