nalidixic acid


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nalidixic acid

 [nal″ĭ-dik´sik]
a quinolone antibacterial agent, active against most gram-negative bacteria causing urinary tract infection including Escherichia coli, Klebsiella and Enterobacter species, and some Proteus species. Pseudomonas species are generally resistant.

nal·i·dix·ic ac·id

(nal-i-dik'sik as'id),
An orally effective antibacterial agent used in the treatment of genitourinary tract infections.

nalidixic acid

/nal·i·dix·ic ac·id/ (nal-ĭ-dik´sik) a synthetic antibacterial agent used in the treatment of genitourinary infections caused by gram-negative organisms.

nalidixic acid

(nā′lĭ-dĭk′sĭk)
n.
An antibacterial drug, C12H12N2O3, used to treat urinary tract infections caused by gram-negative bacteria.

nalidixic acid

[nal′idik′sik]
an antibacterial.
indications It is prescribed in the treatment of certain urinary tract infections.
contraindications Renal or hepatic insufficiency, a history of convulsive disorders, or known hypersensitivity to this drug prohibits its use. It should not be used in children less than 3 months of age and should be used with care in prepubertal children.
adverse effects Quinolones have caused tendon rupture, especially in prepubertal children, and severe hypersensitivity reactions. Among the more serious effects are increased intracranial pressure, seizures, hemolytic anemia in people affected with glucose-6-phosphate dehydrogenase deficiency, and GI and neurological disturbances.

nalidixic acid

Antibiotics An early generation quinolone with a limited antimicrobial palate, primarily used for UTIs. See Quinolone.

nalidixic acid

A quinolone antibiotic drug, effective against GRAM NEGATIVE bacilli, including Proteus species, and much used for urinary infections. The drug is on the WHO official list. Brand names are Negram andUriben.

nal·i·dix·ic ac·id

(nali-diksik asid)
Orally effective antibacterial agent used to treat genitourinary tract infections.

nalidixic acid,

n an antibacterial prescribed in the treatment of urinary tract infections.

nalidixic acid

a naphthylidine derivative that inhibits DNA synthesis. Used for the treatment of urinary tract infections due to susceptible gram-negative bacteria. Side-effects in dogs include vomiting, diarrhea and seizures.
References in periodicals archive ?
coli showed greater sensitivity to nitrofurantoin (47%) and lesser sensitivity to nalidixic acid (15%) as compared to Klebsiella pneumoniae which showed 15% sensitivity to nitrofurantoin and 24% to nalidixic acid in our study similar to another study.
Another research of Karachi is also the evident of high rate of resistance in Shigella against Ampicillin and nalidixic Acid 55.
75 [micro]g (SXT), nalidixic acid 30 [micro]g (NAL), norfloxacin 10 [micro]g (NOR), cefotaxime 30 [micro]g (TAX) and cefixime 5 [micro]g (FIX) was performed using Kirby-Bauer disk diffusion method and results were interpreted using breakpoints recommended by the Clinical Laboratory Standards Institute (CLSI) guidelines 2014 and 2015.
12 Antibiotics used for antibiogram determination of the collected strains among FQ were: norfloxacin, ciprofloxacin, ofloxacin, enoxacin, moxifloxacin, and sparfloxacin and nalidixic acid.
Summary: Different analogs of 1-ethyl-1, 4-dihydro-7-methyH-4-oxo-1, 8-naphthyridine-3-carbohydrazide (carbonyl hydrazone derivatives of Nalidixic acid, H 1-10) and their copper complexes have been synthesized from reaction of Nalidixic acid hydrazide with substituted benzaldehyde.
Selective enrichment broths for GBS are variations of Todd-Hewitt broth, with either 8 [micro]g/mL gentamicin and 15 [micro]l/mL nalidixic acid (TransVag broth) or 10 [micro]g/mL colistin and 15 [micro]l/mL nalidixic acid (Lim broth).
The first quinolone (quinoJ[ine] + -one [compound related to ketone]), nalidixic acid, was isolated as a byproduct of chloroquine (see "quinine," https://wwwnc.
There were intermediate zone of inhibition found on claforan, nalidixic acid, amoxycillin, fosfomycin, fortum, and erythromycin on Mueller Hinton's agar after 24 hours incubation.
Tenders are invited for Supply of 61 -Temocillin,62- Tobramycin 10 mcg ,63- Vancomycin (5 mcg) ,64- Nalidixic Acid (30 mcg) ,65- Quinopriosatine-Dalfopristine ,66- Amoxicillin (E Test Strips) ,67 -Amoxicillin-Clvulanate (E Test Strips) ,68- Azithromycine (E Test Strips) ,69 -Cefepime (E Test Strips) ,70- Cefotaxime (E Test Strips) for Microbiology Department, Medical College
coli showed sensitivity to chloramphenicol(30mg), nalidixic acid (30mg), ciprofloxacin(10mg) and gentamicin(10mg).
Eleven test tubes with saline solution were prepared in duplicate, and the six antibiotics previously selected in the disk diffusion sensitivity test were added: cefaclor, vancomycin, nalidixic acid, cefalotin, chloramphenicol, and cefalexin.