Naked DNA delivery of angiogenic growth factors may be particularly attractive, since it provides prolonged production of the growth factor proteins at the site where they are needed, with a limited amount of protein escaping from that site.
Naked DNA is different from other gene-based delivery techniques because it doesn't use viruses to deliver the genetic material -- the genes are "virus-bare.
This patent effectively renews and reinforces Vical's previously issued patent covering naked DNA injection into muscle or skin to stimulate an immune response systemically.
Naked DNA is different from other gene delivery techniques because it doesn't use viruses to deliver the genetic material -- the genes are "virus-bare" or "naked.
The patent, entitled Gene Therapy by Secretory Gland Expression, covers the delivery of naked DNA
encoding any gene using either viral or non-viral vectors.
Senior Vice President of Science and Medical Affairs said, "Our compacted DNA nanoparticles robustly transfect post-mitotic human cells, achieving up to a 6,900-fold enhancement of gene expression compared to naked DNA
In this first Phase II controlled challenge trial, the MuStDO 5 DNA vaccine will include dose escalation of a naked DNA
agent encoding granulocyte macrophage colony stimulating factor (GM-CSF), an immune system stimulant.
NYSE:AVE), covering the use of Vical's naked DNA
gene transfer technology to deliver a growth factor gene.
NYSE:AVE), rights to use Vical's naked DNA
gene transfer technology to deliver a growth factor gene for which Aventis Pharma holds rights.
Vical (NASDAQ:VICL) is also developing anticancer immunotherapeutics based on its naked DNA
In preclinical testing, Vaxfectin was shown to boost the antibody immune response evoked by naked DNA
vaccination as much as 10-fold without reducing the cell-mediated response.
We are pleased to announce that Merck recently started a trial to test a naked DNA
vaccine for HIV in sero-positive volunteers.