delivery of angiogenic growth factors may be particularly attractive, since it provides prolonged production of the growth factor proteins at the site where they are needed, with a limited amount of protein escaping from that site.
is different from other gene delivery techniques because it doesn't use viruses to deliver the genetic material -- the genes are "virus-bare" or "naked.
In the Phase IIb trial for severe cardiovascular disease, VEGF- 2 is delivered to the ischemic tissue in the heart muscle in the form of naked DNA
plasmid, a non-viral vector.
The patent, entitled Gene Therapy by Secretory Gland Expression, covers the delivery of naked DNA
encoding any gene using either viral or non-viral vectors.
Senior Vice President of Science and Medical Affairs said, "Our compacted DNA nanoparticles robustly transfect post-mitotic human cells, achieving up to a 6,900-fold enhancement of gene expression compared to naked DNA
In this first Phase II controlled challenge trial, the MuStDO 5 DNA vaccine will include dose escalation of a naked DNA
agent encoding granulocyte macrophage colony stimulating factor (GM-CSF), an immune system stimulant.
NYSE:AVE), covering the use of Vical's naked DNA
gene transfer technology to deliver a growth factor gene.
In comparison to vaccinations with naked DNA
, the adenovirus-based vaccine showed a stronger anti-HIV immune response.
NYSE:AVE), rights to use Vical's naked DNA
gene transfer technology to deliver a growth factor gene for which Aventis Pharma holds rights.
including a study in which a vaccine regimen employing Vical's patented naked DNA
non-viral gene delivery technology was used in a prime-boost regimen with naked DNA
plus adjuvant to prime and Merck's non-replicating adenoviral vector to boost.
Vical (NASDAQ:VICL) is also developing anticancer immunotherapeutics based on its naked DNA
Vical's patented naked DNA
technology is a biological method of delivering genes into cells in the body to cause production of desired proteins.