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a nonsteroidal antiinflammatory drug used in treatment of rheumatoid arthritis and osteoarthritis.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Gen-Nabumetone, Nabumetone, Novo-Nabumetone, Relifex (UK), Sandoz

Pharmacologic class: Nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Antiarthritic

Pregnancy risk category C (first and second trimesters), D (third trimester)

FDA Box Warning

Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. Risk may increase with duration of use. Patients with cardiovascular disease or risk factors for it may be at greater risk.

Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation. These events can occur at any time during use and without warning. Elderly patients are at greater risk.

Drug is contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery.


Unknown. Thought to stimulate anti-inflammatory response and block pain impulses by inhibiting cyclooxygenase, an enzyme needed for prostaglandin synthesis.


Tablets: 500 mg, 750 mg

Indications and dosages

Rheumatoid arthritis; osteoarthritis

Adults: 1,000 mg/day P.O. as a single dose or in two divided doses; may increase up to 2,000 mg/day


• Hypersensitivity to drug

• Active GI bleeding or ulcer disease

• History of aspirin- or NSAID-induced asthma, urticaria, or other allergic-type reaction

• Concurrent use of other NSAIDs

• Pregnancy (third trimester)


Use cautiously in:

• severe cardiovascular, renal, or hepatic disease

• history of ulcer disease

• pregnant (first or second trimester) or breastfeeding patients

• children (safety and efficacy not established).


• Give with food or milk to increase absorption.

• In chronic therapy, use lowest effective dosage.

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache, insomnia, malaise, nervousness

CV: vasculitis

EENT: abnormal vision, tinnitus

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, stomatitis, dry mouth, GI bleeding

Skin: pruritus, rash, angioedema

Other: edema, fluid retention, allergic reactions including anaphylaxis


Drug-drug. Acetaminophen: increased risk of adverse renal reactions (with chronic nabumetone use)

Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid: increased risk of bleeding

Antihypertensives, diuretics: decreased nabumetone efficacy

Antineoplastics: increased risk of adverse hematologic reactions

Aspirin, corticosteroids, other NSAIDs, potassium supplements: additive adverse GI effects

Cyclosporine: increased risk of renal toxicity

Insulins, oral hypoglycemics: increased hypoglycemic effect

Methotrexate: increased risk of methotrexate toxicity

Patient monitoring

Watch closely for signs and symptoms of angioedema, anaphylaxis, or other hypersensitivity reactions (including hives, swelling, shortness of breath, and abdominal pain).

• Monitor GI status. Report nutritional deficiencies.

• Assess vital signs.

• Monitor fluid intake and output.

Patient teaching

• Tell patient he may crush tablet if he can't swallow it whole.

• To minimize GI upset, advise patient to take drug with food; eat small, frequent servings of healthy food; and drink plenty of fluids.

• Advise patient to continue taking drug for entire duration prescribed.

Teach patient to recognize and immediately report signs and symptoms of hypersensitivity reaction and angioedema (hives, swelling, shortness of breath, abdominal pain).

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, strength, and alertness.

• Advise patient not to drink alcohol. Tell him to avoid aspirin, ibuprofen, and over-the-counter preparations (unless prescribed).

• Caution female patient not to take drug, especially during third trimester.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


An anti-inflammatory and analgesic drug of the NSAID class, C15H16O2, used primarily to treat osteoarthritis and rheumatoid arthritis.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.


A NON-STEROIDAL ANTI-INFLAMMATORY DRUG used to treat arthritis and other painful conditions. A brand name is Relifex.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about nabumetone

Q. can u take nabumetone and dicfofenac at the same time

A. thanks 4 the info my dr. nurse said to take both,but pharmacy said not to didn't know what to do .

More discussions about nabumetone
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References in periodicals archive ?
Palmer, "Treatment of elderly patients with nabumetone or diclofenac: Gastrointestinal safety profile," Journal of Clinical Gastroenterology, vol.
NSAID classification Non-selective inhibition Acetic acid Proprionic acid Fenamate derivatives derivatives derivatives * Diclofenac * Fenoprofen * Meclofenamate * Etodolac * Flurbiprofen * Mefenamic acid * Indomethacin * Ibuprofen * Sulindac * Ketoprofen * Tolmetin * Naproxen * Oxaprozin Naphthyl alkanone Salicylates * Nabumetone * Aspirin * Diflunisal * Choline magnesium trisalicylate * Salicylate Enolic acid derivatives * Piroxicam * Meloxicam Selective COX-2 inhibition * Celecoxib * Rofecoxib Table 9.
Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients.
While various authors have stated that NSAIDs should be used with caution during orthodontic tooth movement, a recent publication reported that nabumetone, a drug belonging to the NSAID group, reduces the amount of root resorption along with the control of pain from intrusive orthodontic forces, without affecting the pace of tooth movement.9
M2 EQUITYBITES-June 20, 2011-Watson Pharmaceuticals Inc awarded FDA approval for Nabumetone for osteoarthritis and rheumatoid arthritis(C)2011 M2 COMMUNICATIONS
(Canonsburg PA) received approval for its generic version of the osteoarthritis and rheumatoid arthritis drug Nabumetone. The FDA approval allows Mylan to sell 500 milligram and 750 milligram tablets.
The majority of participants (61 percent) reported regular use of NSAIDs within the previous ten years, including 48 percent who used aspirin, 18 percent who used ibuprofen, 5 percent who used naproxen and 4 percent who used nabumetone.
Classification of NSAIDs according to COX-selective properties COX-1 selective Non-selective COX-2 selective Indomethacin Diclofenac Celecoxib Piroxicam Naproxen Etoricoxib Lornoxicam Ibuprofen Parecoxib * Tenoxicam Nabumetone Rofecoxib ([dagger]) Ketoprofen Sulindac Valdecoxib ([dagger]) Ketorolac Lumiracoxib ([dagger]) Mefenamic acid Meloxicam * Parenteral formulation only ([dagger]) Withdrawn from the market, including South Africa.
([dagger]) NSAIDs (diclofenac sodium, diclofenac potassium, diclofenac/misoprostol, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen, ketorolac, meclofenamate, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin, piroxicam, sulindac, tolmetin).
The nonacetylated salicylates, including salsalate, magnesium choline trisalicylate, and diflunisal, as well as several of the nonsalicylate NSAIDs, such as low-dose etodolac, low-dose ibuprofen, and nabumetone, are reportedly less toxic to the GI mucosa than the other NS-NSAIDs.