nabumetone


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nabumetone

 [nah-bu´mĕ-tōn]
a nonsteroidal antiinflammatory drug used in treatment of rheumatoid arthritis and osteoarthritis.

nabumetone

Gen-Nabumetone, Nabumetone, Novo-Nabumetone, Relifex (UK), Sandoz

Pharmacologic class: Nonsteroidal anti-inflammatory drug (NSAID)

Therapeutic class: Antiarthritic

Pregnancy risk category C (first and second trimesters), D (third trimester)

FDA Box Warning

Drug may increase risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke. Risk may increase with duration of use. Patients with cardiovascular disease or risk factors for it may be at greater risk.

Drug increases risk of serious GI adverse events, including bleeding, ulcers, and stomach or intestinal perforation. These events can occur at any time during use and without warning. Elderly patients are at greater risk.

Drug is contraindicated for treatment of perioperative pain in setting of coronary artery bypass graft surgery.

Action

Unknown. Thought to stimulate anti-inflammatory response and block pain impulses by inhibiting cyclooxygenase, an enzyme needed for prostaglandin synthesis.

Availability

Tablets: 500 mg, 750 mg

Indications and dosages

Rheumatoid arthritis; osteoarthritis

Adults: 1,000 mg/day P.O. as a single dose or in two divided doses; may increase up to 2,000 mg/day

Contraindications

• Hypersensitivity to drug

• Active GI bleeding or ulcer disease

• History of aspirin- or NSAID-induced asthma, urticaria, or other allergic-type reaction

• Concurrent use of other NSAIDs

• Pregnancy (third trimester)

Precautions

Use cautiously in:

• severe cardiovascular, renal, or hepatic disease

• history of ulcer disease

• pregnant (first or second trimester) or breastfeeding patients

• children (safety and efficacy not established).

Administration

• Give with food or milk to increase absorption.

• In chronic therapy, use lowest effective dosage.

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache, insomnia, malaise, nervousness

CV: vasculitis

EENT: abnormal vision, tinnitus

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dyspepsia, flatulence, stomatitis, dry mouth, GI bleeding

Skin: pruritus, rash, angioedema

Other: edema, fluid retention, allergic reactions including anaphylaxis

Interactions

Drug-drug. Acetaminophen: increased risk of adverse renal reactions (with chronic nabumetone use)

Anticoagulants, cefamandole, cefoperazone, cefotetan, clopidogrel, eptifibatide, plicamycin, thrombolytics, ticlopidine, tirofiban, valproic acid: increased risk of bleeding

Antihypertensives, diuretics: decreased nabumetone efficacy

Antineoplastics: increased risk of adverse hematologic reactions

Aspirin, corticosteroids, other NSAIDs, potassium supplements: additive adverse GI effects

Cyclosporine: increased risk of renal toxicity

Insulins, oral hypoglycemics: increased hypoglycemic effect

Methotrexate: increased risk of methotrexate toxicity

Patient monitoring

Watch closely for signs and symptoms of angioedema, anaphylaxis, or other hypersensitivity reactions (including hives, swelling, shortness of breath, and abdominal pain).

• Monitor GI status. Report nutritional deficiencies.

• Assess vital signs.

• Monitor fluid intake and output.

Patient teaching

• Tell patient he may crush tablet if he can't swallow it whole.

• To minimize GI upset, advise patient to take drug with food; eat small, frequent servings of healthy food; and drink plenty of fluids.

• Advise patient to continue taking drug for entire duration prescribed.

Teach patient to recognize and immediately report signs and symptoms of hypersensitivity reaction and angioedema (hives, swelling, shortness of breath, abdominal pain).

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, vision, strength, and alertness.

• Advise patient not to drink alcohol. Tell him to avoid aspirin, ibuprofen, and over-the-counter preparations (unless prescribed).

• Caution female patient not to take drug, especially during third trimester.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs mentioned above.

nabumetone

/na·bu·me·tone/ (nah-bu´mĕ-tōn) a nonsteroidal antiinflammatory drug used in the treatment of osteoarthritis and rheumatoid arthritis.

nabumetone

(nə-byo͞o′mə-tōn′)
n.
An anti-inflammatory and analgesic drug of the NSAID class, C15H16O2, used primarily to treat osteoarthritis and rheumatoid arthritis.

nabumetone

A NON-STEROIDAL ANTI-INFLAMMATORY DRUG used to treat arthritis and other painful conditions. A brand name is Relifex.

Patient discussion about nabumetone

Q. can u take nabumetone and dicfofenac at the same time

A. thanks 4 the info my dr. nurse said to take both,but pharmacy said not to didn't know what to do .

More discussions about nabumetone
References in periodicals archive ?
Pharmaceutical company Watson Pharmaceuticals Inc (NYSE:WPI) revealed on Friday the receipt of approval from the United States Food and Drug Administration (FDA) for Nabumetone Tablets USP, 500 mg and 750 mg indicated for the relief of signs and symptoms of osteoarthritis and rheumatoid arthritis.
Other relatively safer drugs, such as nabumetone, low-dose ibuprofen (< 1600 mg/24 hours), and etodolac, are usually listed together with similar effects.
Nuevos analgesicos clasicos: AINES con menos efectos secundarios: Me loxican, Nabumetone, derivados del Tramadol.
Prescription NSAIDs include indomethacin (Indocin[R]), naproxen (Anaprox[R], Naprosyn[R], Naprelan[R]), ketoprofen (Oruvail[R]), nabumetone (Relafen[R]), flurbiprofen (Ansaid[R], diclofenac (Arthrotec[R], Cataflam[R], Voltaren[R]), etodolac (Lodine[R]), meloxicam (Mobic[R]), sulindac (Clinoril[R]), oxaprozin (Daypro[R]), and piroxicam (Feldene[R]).
NSAIDs Used To Treat Lupus(*) Generic Name Brand Name Ibuprofen Motrin, Advil Naproxen Naprosyn, Aleve Sulindac Clinoril Diclofenac Voltaren Piroxicam Feldene Ketoprofen Orudis Diflunisal Dolobid Nabumetone Relafen Etodolac Lodine Oxaprozin Daypro Indomethacin Indocin (*) Brand names included in this fact sheet are provided as examples only and their inclusion does not mean that these products are endorsed by the National Institutes of Health or any other Government agency.
Consider the case of nabumetone (brand name: Relafen), a nonsteroidal anti-inflammatory drug (NSAID), approved by the FDA for the treatment of rheumatoid arthritis and osteoarthritis in 1992.
They are nabumetone, marketed under the trade name Relafen by Beecham Laboratories; oxaprozin, marketed in the United States under the name Durapro by G.
M2 EQUITYBITES-15 July 2010-Mylan Inc gets FDA approval for Nabumetone Tablets USP, 500 mg and 750 mg(C)2010 M2 COMMUNICATIONS http://www.
Most of the subjects (61%) reported regular use of NSAIDs at some time during the preceding 10 years, most commonly aspirin (48%), followed by ibuprofen (18%), naproxen (5%), and nabumetone (4%).
Those on naproxen (topical COX-1 and -2 inhibitor) or nabumetone (COX-1 and -2 inhibitor) had relapses associated with intestinal inflammation.
They reported fewer GI adverse events (endoscopically observed gastric erosion and ulcers) with rofecoxib than with other NSAIDs--naproxen (Naprosyn), ibuprofen (Motrin), diclofenac (Cataflam), nabumetone (Relafen), diclofenac/misoprostol (Arthrotec), and nimesulide.
Paciente Mujer de 80 anos con alta presion y artritis-tiene una terapia de medicamentos incluyendo Rofecoxib, Sulindac y Nabumetone (todos bajo la clasificacion de antiinflamatorios no-esteroidales) en cuyo caso tiene mas que duplicidad de terapia y aumenta el riesgo de efectos adversos de estos.