(17,26-28) Focal high-grade sarcomas, with features similar to myxofibrosarcoma
, have been reported in several cases, especially recurrences.
The morphologic features were those of an epithelioid myxofibrosarcoma
(MFS) of high grade.
Kaun et al., "Patellar tendon reconstruction using a free latissimus dorsi flap following resection of a prepatellar myxofibrosarcoma
: Case report," Journal of Reconstructive Microsurgery, vol.
Due to the vast range of histological appearance at the MFH diagnosed tumors, they were further subdivided into (1) storiform-pleomorphic, (2) myxoid (myxofibrosarcoma
), (3) giant cell, (4) inflammatory, and (5) angiomatoid .
Shinomiya et al., "Modified partial maxillary swing approach for myxofibrosarcoma
in pterygopalatine fossa," Head and Neck, vol.
The scars were reexcised after previous resection of benign lesions (14 cases, 43.74%) or malignant tumor (18 cases, 56.25%; 13 melanomas, one basal cell carcinoma, 2 squamous cell carcinomas, one dermatofibrosarcoma protuberans, and one myxofibrosarcoma
Immunostain for S-100 protein and GNAS 1 mutations can distinguish myxoid liposarcoma and low-grade myxofibrosarcoma
from intramuscular myxomas, respectively [20,21].
DFML can be confused with other more clinically aggressive neoplasms, including myxoid liposarcoma (MLS), low-grade fibromyxoid sarcoma (LFMS), and myxofibrosarcoma
, especially the low-grade type, highlighting the importance of its recognition.
Histological examination diagnosed the following types of spinal and paraspinal sarcomas: 8 cases of chordoma; 5 cases each of osteosarcoma, undifferentiated pleomorphic sarcoma, and malignant peripheral nerve sheath tumor; 2 cases each of chondrosarcoma and leiomyosarcoma; and 1 case each of myxofibrosarcoma
, malignant solitary fibrous tumor, and malignant myoepithelioma.
Soft-tissue sarcomas are tumors arising from extraskeletal connective tissues and from Schwann cells and include fibrosarcoma, liposarcoma, hemangiopericytoma, rhabdomyosarcoma, lymphangiosarcoma, malignant fibrous histiocytoma, leiomyosarcoma, myxosarcoma, myxofibrosarcoma
, mesenchymoma, spindle cell tumors, and malignant peripheral nerve sheath tumors (neurofibrosarcoma, Schwannoma).
Examples of patients with aggressive cancers, such as pancreatic cancer, grade IV glioblastoma, stage 3 serous carcinoma of the uterus, stage 4 myxofibrosarcoma
, stage 4 invasive ductal carcinoma, chronic myelogenous leukemia, stage 4 colon cancer, and many others once diagnosed and treated for MSCIS, have resolution or stabilization of their cancers as evidenced at my clinic.
It was, according to the final biopsy result, "low-grade malignant peripheral nerve sheath tumor," a "Myxoid Malignant Fibrous Histiocytoma (Myxofibrosarcoma
) to be specific.