myxoedema


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myx·e·de·ma

(miks'ĕ-dē'mă)
Nonpitting waxy edema of the skin, often most pronounced in the face and shins (pretibial myxedema), owing to subcutaneous deposition of mucoid material in hypothyroidism.
Synonym(s): myxoedema.
[myx- + G. oidēma, swelling]

myxoedema

The general effects of severe underactivity of the thyroid gland (HYPOTHYROIDISM). These include dry, yellow, cold, scaly, thickened and coarse skin, scanty hair, loss of the eyebrows, lethargy, marked slowing of body and mind, absence of menstrual periods, accumulation of mucoid deposits in the body, ANGINA PECTORIS, ANAEMIA and HEART FAILURE. A frank PSYCHOSIS with delusions and hallucinations may occur. Death may result from failure to maintain body temperature. Most of these effects can be prevented or reversed by giving thyroid hormone.

myxoedema

the condition occurring in adults due to under-secretion of THYROXINE. There is a decrease of METABOLIC RATE, an increase in subcutaneous fat, a coarsening of the skin and mental and physical sluggishness.

myxoedema

boggy swelling of face and hands, bradycardia, anhidrosis, constipation, feeling cold and general slowness, characteristic of hypothyroidism
  • congenital myxoedema; cretinism congenital underproduction of thyroxine; if left untreated leads to marked myxoedema and severe mental retardation

myx·e·de·ma

(miks'ĕ-dē'mă) [MIM*255900]
Hypothyroidism with a relatively hard edema of subcutaneous tissue, with increased content of mucins (proteoglycans) in the interstitial fluid; characterized by somnolence, slow mentation, dryness and loss of hair, increased fluid in body cavities such as the pericardial sac, subnormal temperature, hoarseness, muscle weakness, and slow return of a muscle to the neutral position after a tendon jerk.
Synonym(s): myxoedema.
[myx- + G. oidēma, swelling]
References in periodicals archive ?
The whole problem of goiter or myxoedema, of cretinism and exophthalmia, seemed to resolve itself into a question of the presence or absence of a few pinches of iodine in our thyroids.
Thyroid function testing is suggested as part of baseline laboratory studies, because of the clinical similarity to pretibial myxoedema.
A variable incidence of hypertension was observed in cases of myxoedema by different workers in the field.
Ord WM: On myxoedema, a term proposed to be applied to an essential condition in the "cretinoid" affection occasionally observed in middle-aged women.
In reality, Mr yeltsin (above) was suffering from a form of low thyroid function known as myxoedema or hypothyroidism.
Myxoedema was first effectively treated in 1891 by George Murray using a subcutaneous injection of an extract of sheep's thyroid and later, Edward Fox demonstrated that oral therapy was equally effective.
Here he carried out important experimental studies in three fields: He showed that the clinical picture of myxoedema could be reproduced in animals by total thyroidectomy; worked on rabies--then a much-feared danger of dog bites in this country; and on localisation of function in the various parts of the brain and spinal cord--hence the development of his wax.
Danilewitz M, Barbezat GO, Helman GA, et al: Myxoedema presenting with ascites: a case report.
Deficits of thyroid hormone produces cutaneous changes like dryness, ichthyosis, puffiness of face, pedal edema, myxoedema, diffuse hair loss, brittle nails, carotenemias etc.
INTRODUCTION: The most commonly observed symptoms of myopathy due to hypothyroidism are proximal weakness, cramps, painful muscles, myxoedema on percussion, delay in deep tendon reflexes and development of muscle hypertrophy.
Autoimmunity:AA is associated with other autoimmune diseases, such as myxoedema and pernicious anemia.