myxoedema


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myx·e·de·ma

(miks'ĕ-dē'mă)
Nonpitting waxy edema of the skin, often most pronounced in the face and shins (pretibial myxedema), owing to subcutaneous deposition of mucoid material in hypothyroidism.
Synonym(s): myxoedema.
[myx- + G. oidēma, swelling]

myxoedema

The general effects of severe underactivity of the thyroid gland (HYPOTHYROIDISM). These include dry, yellow, cold, scaly, thickened and coarse skin, scanty hair, loss of the eyebrows, lethargy, marked slowing of body and mind, absence of menstrual periods, accumulation of mucoid deposits in the body, ANGINA PECTORIS, ANAEMIA and HEART FAILURE. A frank PSYCHOSIS with delusions and hallucinations may occur. Death may result from failure to maintain body temperature. Most of these effects can be prevented or reversed by giving thyroid hormone.

myxoedema

the condition occurring in adults due to under-secretion of THYROXINE. There is a decrease of METABOLIC RATE, an increase in subcutaneous fat, a coarsening of the skin and mental and physical sluggishness.

myx·e·de·ma

(miks'ĕ-dē'mă) [MIM*255900]
Hypothyroidism with a relatively hard edema of subcutaneous tissue, with increased content of mucins (proteoglycans) in the interstitial fluid; characterized by somnolence, slow mentation, dryness and loss of hair, increased fluid in body cavities such as the pericardial sac, subnormal temperature, hoarseness, muscle weakness, and slow return of a muscle to the neutral position after a tendon jerk.
Synonym(s): myxoedema.
[myx- + G. oidēma, swelling]
References in periodicals archive ?
"A case of myxoedema treated by taking extract of thyroid by the mouth." BMJ, 1892; 2:941.
The whole problem of goiter or myxoedema, of cretinism and exophthalmia, seemed to resolve itself into a question of the presence or absence of a few pinches of iodine in our thyroids.
Laurberg, "Weight loss after therapy of hypothyroidism is mainly caused by excretion of excess body water associated with myxoedema," The Journal of Clinical Endocrinology & Metabolism, vol.
Hypothyroidism has a wide clinical spectrum ranging from a frank state of myxoedema, end-organ impact and multisystem failure to an asymptomatic subclinical state.
reported that oral absorption of T4 is variable, but clinical response occurs quickly even in myxoedema ileus after comparing oral T4 500 [micro]g stat dose followed by 100 [micro]g/daywithIVT4inpatientswithmyxedema [6].
Pregnant women and patients who did not fulfill the inclusion criteria for obese and non-obese subjects at time of interview and those who had congenital, mental, or endocrine disorders (e.g., Myxoedema and Cushing's syndrome) or metabolic disorders like diabetes mellitus, cardiovascular disease, and congestive heart failure were excluded from the study.
It covers a wide spectrum of clinical & biochemical disease, from clinically unapparent disease to myxoedema and coma.
(2) Almost one third of all cases of myxoedema lead to secondary hypertension.
In addition to the eye features, swelling can occur elsewhere for example in the skin of the shin (pretibial myxoedema) or in the finger nails (thyroid acropachy).
Thus he would illustrate myxoedema by reading from Cronin's The Citadel and thyroid eye disease using the comic character Evil-eyed Fleegle of Little Abner fame.
"Note on the treatment of myxoedema by hypodermic injections of an extract of the thyroid gland of a sheep." BMJ, 1891; 2:796-797.
In reality, Mr yeltsin (above) was suffering from a form of low thyroid function known as myxoedema or hypothyroidism.