Alternative anabolic agents such as nandrolone or oxandrolone exhibit significantly greater selectivity for myotropic
properties, with minimal androgenic effects (myotrophic: androgenic activity ratio of 12 and 13, resp.) .
These processes are also observed in the mouse model of Chagas disease caused by a myotropic
Trypanosoma cruzi strain, which develops a progressive inflammatory response and fibrosis in the heart, along with an intense skeletal myositis, in the chronic phase of infection .
This peptide was first identified through pharmacological screening for myotropic
activity and was subsequently, in addition, found to have a broad spectrum of antimicrobial activity, albeit relatively low potency.
Because our previous studies of vaccination have been performed with the reticulotropic Y strain (TcII), it was our intention to extend these studies using experimental infections with two myotropic
strains of the parasites belonging to TcI (Colombian) and TcII (Brazil).
Its anabolic (myotropic
) effects are observed as the development of a larger mass of muscles, increased maturity of skeletal bones and increased mineralization (C.D.
a novel myotropic
neuropeptide from the grey fleshfly.
and plasma-calcium modulating effects of calcitonin gene-related peptide (CGRP).
Experimental Chagas' disease: Electrophysio logy and cell composition of the neuromyopathic inflammatory lesions in mice infected with a myotropic
and a pantropic strain of Trypanosoma cruzi.
Relative binding affinities of testosterone, 19-nortestosterone and their 5-[alpha]-reduced derivatives to the androgen receptor and to other androgen-binding proteins--a suggested role of 5-[alpha]-reductive steroid-metabolism in the dissociation of myotropic
and androgenic activities of 19-nortestosterone.
This novel peptide was named balteatide, reflecting its species of origin and its structural similarity to a previously reported myotropic
peptide named sauvatide, from the skin secretion of Phyllomedusa sauvagei .
Hontebeyrie-Joskowicz, "Susceptible mice present higher macrophage activation than resistant mice during infections with myotropic
strains of Trypanosoma cruzi," Parasite Immunology, vol.
Peptidergic neurons in the snail Helix pomatia: distribution of neurons in the central and peripheral nervous system that react with an antibody raised to an insect myotropic
neuropeptide, leucokinin I.