Pharmacological properties of Vochysia Haenkeana (Vochysiaceae) extract to neutralize the neuromuscular blockade induced by Bothropstoxin-I (Lys49 Phospholipase A2) myotoxin
. Adv Pharm Bull 2017; 7: 433-439, doi: 10.15171/apb.2017.052.
research in foodstuffs in the Czech Republic in the 90th year.
Tomaz et al., "Inhibition of myotoxic activity of Bothrops asper myotoxin
II by the anti-trypanosomal drug suramin," Journal of Molecular Biology, vol.
The comparison of 50 amino acids residues from Bmoo-SII placed it in the phospholipase [A.sub.2] superfamily with high identity to Myotoxin
II from B.
When the target [PLA.sub.2]s are Lys49 homologues or Asp49 myotoxins
, the sbPLIs are specifically called myotoxin
inhibitor proteins (MIPs) [85, 86].
(3,4,7) Although federal and state health laboratories have not identified the heat-stable myotoxin
in Haff disease, mice fed samples of toxic buffalo fish developed histopathological evidence of rhabdomyolysis with renal tubular myoglobin and myoglobinuria.
Various other mechanisms have been suggested--directly acting cardiotoxin (5), myotoxin
causing cardiac muscle damage, (6) coronary vasospasm, (7) electrolyte disturbance, (8) severe hypotension (9) and disturbance of autonomic innervation of the heart.
Stabeli et al., "Structural and functional analysis of BmjMIP, a phospholipase [A.sub.2] myotoxin
inhibitor protein from Bothrops moojeni snake plasma," Biochemical and Biophysical Research Communications, vol.
A new muscle damaging toxin, myotoxin
II, from the venom of the snake Bothrops asper (terciopelo).
Natural phospholipase A(2) myotoxin
inhibitor proteins from snakes, mammals and plants.