myositis ossificans progressiva


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my·o·si·tis os·sif·'i·cans pro·gres·si·'va

a rare and frequently fatal mutation, beginning in early life, characterized by progressive ossification of the muscles; it is not strictly a myositis, but a noninflammatory ossification.
A rare idiopathic or autosomal dominant MIM 135100 condition of irregular penetration and pre-pubertal onset, in which connective/interstitial tissues undergo extensive fibrosis and heterotopic ossification of ligaments, tendons, muscle, fascia, aponeuroses and skin, first seen in late childhood as firm masses. The abnormal development of bone may lead to stiffness in affected areas and may also limit movement in affected joints, e.g., knees, wrists, shoulders, spine, and/or neck
DiffDx Osseous metaplasia, myositis ossificans, extraskeletal osteosarcoma
References in periodicals archive ?
Myositis ossificans progressiva is a rare autosomal dominant disease, inherited as a trait with variable expression and complete penetrance.
1) which occurs in most of the cases of myositis ossificans progressiva. This was noticed by the parents of the patient during childhood.
Myositis ossificans progressiva is generally a clinical diagnosis that is based on the presence of congenital anomalies of the great toes, progressive heterotopic ossification and the classical pattern of disease progression.
Myositis ossificans progressiva is a rare congenital disease of progressive ectopic ossification of soft tissues.
5 Some authors believe myositis ossificans traumatica to be an inadequately descriptive term because in as many as 25% of cases, no history of trauma can be obtained.6 Apart from myositis ossificans progressiva, which has a genetic origin, European authors have described two other variants of myositis ossificans as traumatic myositis ossificans circumscripta and atraumatic myositis ossificans circumscripta.7 These authors have suggested an infective origin to atraumatic myositis ossificans.8 In the present case report history of trauma during mastication was estab- lished.